| Cytotoxic Amides and Quinolones from Clausena lansium | |
| Song, Wei-Wu1,2; Zeng, Guang-Zhi1; Peng, Wen-Wen1; Chen, Ke-Xian1,2; Tan, Ning-Hua1 | |
| 2014-02-01 | |
| 发表期刊 | HELVETICA CHIMICA ACTA
 |
| ISSN | 0018-019X |
| 卷号 | 97期号:2页码:298-305 |
| 摘要 | Two new amides, claulansamides A and B (1 and 2, resp.), together with five known amides, 3-7 and six known quinolones, 8-13, were isolated from the stems and roots of Clausena lansium. Their structures were elucidated on the basis of extensive spectroscopic methods. Their absolute configurations were determined by single-crystal X-ray diffraction technique, CD, and optical rotation. HPLC Chiral separation of 1 afforded two enantiomers, (+)- and (-)-claulansamide A, respectively. Compounds 9, 12, and 13 were isolated from the genus Clausena for the first time. All compounds were evaluated for their cytotoxic activities against A549, BGC-823, and HeLa cancer cell lines. However, only 9 showed cytotoxic activity against A549 cell line with an IC50 value of 46.3 mu M, and 11 against BGC-823 and HeLa cell lines with the IC50 values of 55.0 and 14.7 mu M, respectively. |
| 关键词 | Quinolones Clausena Lansium Cytotoxic Activity Claulansamides a And b Amides |
| 学科领域 | Chemistry, Multidisciplinary |
| DOI | 10.1002/hlca.201300323 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000331959500012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18055 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Wei-Wu,Zeng, Guang-Zhi,Peng, Wen-Wen,et al. Cytotoxic Amides and Quinolones from Clausena lansium[J]. HELVETICA CHIMICA ACTA,2014,97(2):298-305. |
| APA | Song, Wei-Wu,Zeng, Guang-Zhi,Peng, Wen-Wen,Chen, Ke-Xian,&Tan, Ning-Hua.(2014).Cytotoxic Amides and Quinolones from Clausena lansium.HELVETICA CHIMICA ACTA,97(2),298-305. |
| MLA | Song, Wei-Wu,et al."Cytotoxic Amides and Quinolones from Clausena lansium".HELVETICA CHIMICA ACTA 97.2(2014):298-305. |
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