Cytotoxic Amides and Quinolones from Clausena lansium
Song, Wei-Wu1,2; Zeng, Guang-Zhi1; Peng, Wen-Wen1; Chen, Ke-Xian1,2; Tan, Ning-Hua1
2014-02-01
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号97期号:2页码:298-305
摘要Two new amides, claulansamides A and B (1 and 2, resp.), together with five known amides, 3-7 and six known quinolones, 8-13, were isolated from the stems and roots of Clausena lansium. Their structures were elucidated on the basis of extensive spectroscopic methods. Their absolute configurations were determined by single-crystal X-ray diffraction technique, CD, and optical rotation. HPLC Chiral separation of 1 afforded two enantiomers, (+)- and (-)-claulansamide A, respectively. Compounds 9, 12, and 13 were isolated from the genus Clausena for the first time. All compounds were evaluated for their cytotoxic activities against A549, BGC-823, and HeLa cancer cell lines. However, only 9 showed cytotoxic activity against A549 cell line with an IC50 value of 46.3 mu M, and 11 against BGC-823 and HeLa cell lines with the IC50 values of 55.0 and 14.7 mu M, respectively.
关键词Quinolones Clausena Lansium Cytotoxic Activity Claulansamides a And b Amides
资助信息National New Drug Innovation Major Project of China [2011ZX09307-002-02]; National Natural Science Foundation of China [U1032602, 91013002, 30725048]; National Basic Research Program of China [2009CB522300]; Fund of Chinese Academy of Sciences (Hundred Talents Program); Natural Science Foundation of Yunnan Province [2012GA003]
学科领域Chemistry, Multidisciplinary
DOI10.1002/hlca.201300323
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000331959500012
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18055
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Song, Wei-Wu,Zeng, Guang-Zhi,Peng, Wen-Wen,et al. Cytotoxic Amides and Quinolones from Clausena lansium[J]. HELVETICA CHIMICA ACTA,2014,97(2):298-305.
APA Song, Wei-Wu,Zeng, Guang-Zhi,Peng, Wen-Wen,Chen, Ke-Xian,&Tan, Ning-Hua.(2014).Cytotoxic Amides and Quinolones from Clausena lansium.HELVETICA CHIMICA ACTA,97(2),298-305.
MLA Song, Wei-Wu,et al."Cytotoxic Amides and Quinolones from Clausena lansium".HELVETICA CHIMICA ACTA 97.2(2014):298-305.
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