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题名: Cytotoxic Amides and Quinolones from Clausena lansium
作者: Song, Wei-Wu1, 2; Zeng, Guang-Zhi1; Peng, Wen-Wen1; Chen, Ke-Xian1, 2; Tan, Ning-Hua1
刊名: HELVETICA CHIMICA ACTA
关键词: Quinolones ; Clausena lansium ; Cytotoxic activity ; Claulansamides A and B ; Amides
英文摘要: Two new amides, claulansamides A and B (1 and 2, resp.), together with five known amides, 3-7 and six known quinolones, 8-13, were isolated from the stems and roots of Clausena lansium. Their structures were elucidated on the basis of extensive spectroscopic methods. Their absolute configurations were determined by single-crystal X-ray diffraction technique, CD, and optical rotation. HPLC Chiral separation of 1 afforded two enantiomers, (+)- and (-)-claulansamide A, respectively. Compounds 9, 12, and 13 were isolated from the genus Clausena for the first time. All compounds were evaluated for their cytotoxic activities against A549, BGC-823, and HeLa cancer cell lines. However, only 9 showed cytotoxic activity against A549 cell line with an IC50 value of 46.3 mu M, and 11 against BGC-823 and HeLa cell lines with the IC50 values of 55.0 and 14.7 mu M, respectively.
出版日期: 2014-02-01
卷号: 97, 期号:2, 页码:298-305
DOI标识: 10.1002/hlca.201300323
语种: 英语
ISSN号: 0018-019X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18055
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Song,Wei-Wu;Zeng,Guang-Zhi;Peng,Wen-Wen;Chen,Ke-Xian;Tan,Ning-Hua.Cytotoxic Amides and Quinolones from Clausena lansium,HELVETICA CHIMICA ACTA,2014,97(2):298-305
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