Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria
Shi, Li-Shian1,2; Kuo, Sheng-Chu3; Sun, Han-Dong4; Morris-Natschke, Susan L.5; Lee, Kuo-Hsiung5,6,7; Wu, Tian-Shung2,5
2014-03-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896 ; 0968-0896
卷号22期号:6页码:1889-1898
摘要Eight new cardiac glycosides/aglycones (antiaritoxiosides A-G, 1-7, and antiarotoxinin B, 8), two new coumarins (anticarins A-B, 41-42), and two new flavanones (antiarones L-K, 43-44) were isolated from trunk bark of Antiaris toxicaria together with 53 known compounds. The new structures were established by extensive analysis of spectroscopic data. Compound 1 (10-carboxy and 3 alpha-hydroxy) and compounds 3-6 (10-hydroxy) contain unique substituents that are rarely found in cardiac glycosides. The cytotoxic effects of isolated compounds against ten human cancer cell lines, KB, KB-VIN, A549, MCF-7, U-87-MG, PC-3, 1A9, CAKI-1, HCT-9 and S-KMEL-2, were tested using the sulforhodamine B assay. Five compounds (12, 16, 20, 22, and 31) showed significant cytotoxicity against all ten cancer cell lines, with notable potency at the ng/mL level against some cell lines, which merits further development as clinical trial candidates. (C) 2014 Published by Elsevier Ltd.
关键词Antiaris Toxicaria Cardiac Glycosides Coumarins Cytotoxicity
资助信息National Science Council, Taiwan, Republic of China; NIH [CA-177584-01]; National Science Council, Taiwan, Republic of China; NIH [CA-177584-01]
学科领域Biochemistry & Molecular Biology ; Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Medicinal ; Chemistry, Organic ; Chemistry, Organic
DOI10.1016/j.bmc.2014.01.052
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000332409700012
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18053
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan
2.Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan
3.China Med Univ, Grad Inst Pharmaceut Chem, Taichung 401, Taiwan
4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
5.Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA
6.China Med Univ, Dept Pharm, Taichung 401, Taiwan
7.China Med Univ, Chinese Med Res & Dev Ctr, Taichung 401, Taiwan
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GB/T 7714
Shi, Li-Shian,Kuo, Sheng-Chu,Sun, Han-Dong,et al. Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2014,22(6):1889-1898.
APA Shi, Li-Shian,Kuo, Sheng-Chu,Sun, Han-Dong,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung,&Wu, Tian-Shung.(2014).Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria.BIOORGANIC & MEDICINAL CHEMISTRY,22(6),1889-1898.
MLA Shi, Li-Shian,et al."Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria".BIOORGANIC & MEDICINAL CHEMISTRY 22.6(2014):1889-1898.
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