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题名: The Apoptotic Effect of D Rhamnose beta-Hederin, a Novel Oleanane-Type Triterpenoid Saponin on Breast Cancer Cells
作者: Cheng, Lin1; Xia, Tian-Song1; null(王易芬)2; Zhou, Wenbin1; Liang, Xiu-Qing1; Xue, Jin-Qiu1; Shi, Liang1; Wang, Ying1; Ding, Qiang1
刊名: PLOS ONE
关键词: OXYGEN SPECIES GENERATION ; BCL-2 FAMILY PROTEINS ; PLATYCODON-GRANDIFLORUM ; GINSENOSIDE RH2 ; HEPATOMA-CELLS ; MAPK PATHWAYS ; ANTICANCER ; ACTIVATION ; INDUCTION ; DEATH
英文摘要: There is growing interest in development of natural products as anti-cancer and chemopreventive agents. Many triterpenoids have been proved as potential agents for chemoprevention and therapy of breast cancer. Ginsenosides from ginseng, which mostly belong to dammarane-type triterpenoids, have gained great attention for their anti-breast cancer activity with diverse mechanisms. However, studies of other kinds of triterpenoid saponins on breast cancer are limited. Previously, we purified and identified a novel oleanane-type triterpene saponin named D Rhamnose beta-hederin (DR beta-H) from Clematis ganpiniana, a Chinese traditional anti-tumor herb. In the present study, DR beta-H showed strong inhibitory activity on the growth of various breast cancer cells and induced apoptosis in these cells. DR beta-H inhibited PI3K/AKT and activated ERK signaling pathway. PI3K inhibitor LY294002 synergistically enhanced DR beta-H-induced apoptosis whereas MEK inhibitor U0126 reduced the apoptosis rate. Moreover, DR beta-H regulated the ratio of pro-apoptotic and anti-apoptotic Bcl-2 family proteins. Furthermore, DR beta-H induced depolarization of mitochondrial membrane potential which released Apaf-1 and Cytochrome C from the inter membrane space into the cytosol, where they promoted caspase-9 and caspase-3 activation. This is the first report on the pro-apoptotic effects of DR beta-H, a novel oleanane-type triterpenoid saponin, on breast cancer cells and its comprehensive apoptosis pathways. It implied that oleanane-type triterpenoid saponin DR beta-H could be a promising candidate for chemotherapy of breast cancer.
出版日期: 2014-03-06
卷号: 9, 期号:3, 页码:e90848
DOI标识: 10.1371/journal.pone.0090848
语种: 英语
ISSN号: 1932-6203
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18051
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Breast Dis Ctr, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China

Recommended Citation:
Cheng,Lin;Xia,Tian-Song;Wang,Yi-Fen;Zhou,Wenbin;Liang,Xiu-Qing;Xue,Jin-Qiu;Shi,Liang;Wang,Ying;Ding,Qiang.The Apoptotic Effect of D Rhamnose beta-Hederin, a Novel Oleanane-Type Triterpenoid Saponin on Breast Cancer Cells,PLOS ONE,2014,9(3):e90848
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