| Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus | |
| Zhou, Wen-Bing1,2; Zeng, Guang-Zhi1; Xu, Hui-Min1,2; He, Wen-Jun1; Zhang, Yu-Mei1; Tan, Ning-Hua1 | |
| 通讯作者 | Tan, NH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West C, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China. ; nhtan@mail.kib.ac.cn |
| 2014-03-01 | |
| 发表期刊 | FITOTERAPIA
 |
| ISSN | 0367-326X |
| 卷号 | 93页码:98-104 |
| 摘要 | Six new shionane-type triterpenes, astershionones A-F (1-6), were obtained from the roots and rhizomes of Aster tataricus. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configuration of 1 was determined by single crystal X-ray diffraction analysis and CD analysis. 3 showed inhibitory activity against HBsAg and HBeAg secretion with IC50 values of 23.0 and 23.1 mu M, and cytotoxicity against HepG 2.2.15 cells with a CC50 value of 170.5 mu M. 3 also exhibited inhibitory activity against HBV DNA replication with an IC50 value of 22.4 mu M (C) 2014 Elsevier B.V. All rights reserved. |
| 关键词 | Aster Tataricus Shionane-type Triterpenes Astershionones A-f Anti-hbv |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1016/j.fitote.2013.12.021 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000333494500012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18046 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West C, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,et al. Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus[J]. FITOTERAPIA,2014,93:98-104. |
| APA | Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,He, Wen-Jun,Zhang, Yu-Mei,&Tan, Ning-Hua.(2014).Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus.FITOTERAPIA,93,98-104. |
| MLA | Zhou, Wen-Bing,et al."Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus".FITOTERAPIA 93(2014):98-104. |
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| Zhou-2014-Astershion（506KB） | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |||
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