Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus
Zhou, Wen-Bing1,2; Zeng, Guang-Zhi1; Xu, Hui-Min1,2; He, Wen-Jun1; Zhang, Yu-Mei1; Tan, Ning-Hua1
2014-03-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号93页码:98-104
摘要Six new shionane-type triterpenes, astershionones A-F (1-6), were obtained from the roots and rhizomes of Aster tataricus. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configuration of 1 was determined by single crystal X-ray diffraction analysis and CD analysis. 3 showed inhibitory activity against HBsAg and HBeAg secretion with IC50 values of 23.0 and 23.1 mu M, and cytotoxicity against HepG 2.2.15 cells with a CC50 value of 170.5 mu M. 3 also exhibited inhibitory activity against HBV DNA replication with an IC50 value of 22.4 mu M (C) 2014 Elsevier B.V. All rights reserved.
关键词Aster Tataricus Shionane-type Triterpenes Astershionones A-f Anti-hbv
资助信息National New Drug Innovation Major Project of China [2011ZX09307-002-02]; National Natural Science Foundation of China [U1032602, 91013002, 21102152]; Natural Science Foundation of Yunnan Province [2012GA003, 2011FZ206]; Foundation of Chinese Academy of Sciences (Hundred Talents Program)
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18046
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West C, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,et al. Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus[J]. FITOTERAPIA,2014,93:98-104.
APA Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,He, Wen-Jun,Zhang, Yu-Mei,&Tan, Ning-Hua.(2014).Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus.FITOTERAPIA,93,98-104.
MLA Zhou, Wen-Bing,et al."Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus".FITOTERAPIA 93(2014):98-104.
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