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题名: Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus
作者: Zhou, Wen-Bing1, 2; Zeng, Guang-Zhi1; Xu, Hui-Min1, 2; He, Wen-Jun1; Zhang, Yu-Mei1; Tan, Ning-Hua1
刊名: FITOTERAPIA
关键词: Aster tataricus ; Shionane-type triterpenes ; Astershionones A-F ; Anti-HBV
英文摘要: Six new shionane-type triterpenes, astershionones A-F (1-6), were obtained from the roots and rhizomes of Aster tataricus. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configuration of 1 was determined by single crystal X-ray diffraction analysis and CD analysis. 3 showed inhibitory activity against HBsAg and HBeAg secretion with IC50 values of 23.0 and 23.1 mu M, and cytotoxicity against HepG 2.2.15 cells with a CC50 value of 170.5 mu M. 3 also exhibited inhibitory activity against HBV DNA replication with an IC50 value of 22.4 mu M (C) 2014 Elsevier B.V. All rights reserved.
出版日期: 2014-03-01
卷号: 93, 页码:98-104
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal ; Pharmacology & Pharmacy
ISSN号: 0367-326X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18046
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West C, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Zhou,Wen-Bing;Zeng,Guang-Zhi;Xu,Hui-Min;He,Wen-Jun;Zhang,Yu-Mei;Tan,Ning-Hua.Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus,FITOTERAPIA,2014,93():98-104
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