中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
作者: Yue, Wen1, 2; Chen, Ziheng1, 2; null(刘海洋)3; Yan, Chen3; Chen, Ming1, 2; Feng, Du4; Yan, Chaojun; Wu, Hao1, 2; Du, Lei1, 2; Wang, Yueying1, 2; Liu, Jinhua4; Huang, Xiaohu5; Xia, Laixin1; Liu, Lei1; Wang, Xiaohui1; Jin, Haijing1; Wang, Jun1; Song, Zhiyin6; null(郝小江)3; Chen, Quan1, 2, 4
刊名: CELL RESEARCH
关键词: mitochondrial fusion ; mitofusin1/2 ; deubiquitinase USP30 ; 15-Oxospiramilactone
英文摘要: Mitochondrial fusion is a highly coordinated process that mixes and unifies the mitochondrial compartment for normal mitochondrial functions and mitochondrial DNA inheritance. Dysregulated mitochondrial fusion causes mitochondrial fragmentation, abnormal mitochondrial physiology and inheritance, and has been causally linked with a number of neuronal diseases. Here, we identified a diterpenoid derivative 15-oxospiramilactone (S3) that potently induced mitochondrial fusion to restore the mitochondrial network and oxidative respiration in cells that are deficient in either Mfn1 or Mfn2. A mitochondria-localized deubiquitinase USP30 is a target of S3. The inhibition of USP30 by S3 leads to an increase of non-degradative ubiquitination of Mfn1/2, which enhances Mfn1 and Mfn2 activity and promotes mitochondrial fusion. Thus, through the use of an inhibitor of USP30, our study uncovers an unconventional function of non-degradative ubiquitination of Mfns in promoting mitochondrial fusion.
出版日期: 2014-04-01
卷号: 24, 期号:4, 页码:482-496
DOI标识: 10.1038/cr.2014.20
语种: 英语
ISSN号: 1001-0602
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18040
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Yue-2014-A small natural mole.pdf(1659KB)----开放获取View Download

作者单位: 1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Lab Apoptosis & Mitochondrial Biol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources W, Kunming 650204, Yunnan, Peoples R China
4.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Inst Mol Med, Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
6.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hunan, Peoples R China

Recommended Citation:
Yue,Wen;Chen,Ziheng;Liu,Haiyang;Yan,Chen;Chen,Ming;Feng,Du;Yan,Chaojun;Wu,Hao;Du,Lei;Wang,Yueying;Liu,Jinhua;Huang,Xiaohu;Xia,Laixin;Liu,Lei;Wang,Xiaohui;Jin,Haijing;Wang,Jun;Song,Zhiyin;Hao,Xiaojiang;Chen,Quan.A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30,CELL RESEARCH,2014,24(4):482-496
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yue, Wen]'s Articles
[Chen, Ziheng]'s Articles
[Liu, Haiyang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yue, Wen]‘s Articles
[Chen, Ziheng]‘s Articles
[Liu, Haiyang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Yue-2014-A small natural mole.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace