A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
Yue, Wen1,2; Chen, Ziheng1,2; Liu, Haiyang3; Yan, Chen3; Chen, Ming1,2; Feng, Du4; Yan, Chaojun; Wu, Hao1,2; Du, Lei1,2; Wang, Yueying1,2; Liu, Jinhua4; Huang, Xiaohu5; Xia, Laixin1; Liu, Lei1; Wang, Xiaohui1; Jin, Haijing1; Wang, Jun1; Song, Zhiyin6; Hao, Xiaojiang3; Chen, Quan1,2,4
2014-04-01
发表期刊CELL RESEARCH
ISSN1001-0602
卷号24期号:4页码:482-496
摘要Mitochondrial fusion is a highly coordinated process that mixes and unifies the mitochondrial compartment for normal mitochondrial functions and mitochondrial DNA inheritance. Dysregulated mitochondrial fusion causes mitochondrial fragmentation, abnormal mitochondrial physiology and inheritance, and has been causally linked with a number of neuronal diseases. Here, we identified a diterpenoid derivative 15-oxospiramilactone (S3) that potently induced mitochondrial fusion to restore the mitochondrial network and oxidative respiration in cells that are deficient in either Mfn1 or Mfn2. A mitochondria-localized deubiquitinase USP30 is a target of S3. The inhibition of USP30 by S3 leads to an increase of non-degradative ubiquitination of Mfn1/2, which enhances Mfn1 and Mfn2 activity and promotes mitochondrial fusion. Thus, through the use of an inhibitor of USP30, our study uncovers an unconventional function of non-degradative ubiquitination of Mfns in promoting mitochondrial fusion.
关键词Mitochondrial Fusion Mitofusin1/2 Deubiquitinase Usp30 15-oxospiramilactone
资助信息Natural Science Foundation of China (NSFC) [91213304, 81130045]; Ministry of Sciences and Technology [2011CB910903, 2010CB912204]; NSFC-joint foundation of Yunnan Province [U1032603]
学科领域Cell Biology
DOI10.1038/cr.2014.20
收录类别SCI
语种英语
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000334400600010
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18040
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Lab Apoptosis & Mitochondrial Biol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources W, Kunming 650204, Yunnan, Peoples R China
4.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Inst Mol Med, Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
6.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hunan, Peoples R China
推荐引用方式
GB/T 7714
Yue, Wen,Chen, Ziheng,Liu, Haiyang,et al. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30[J]. CELL RESEARCH,2014,24(4):482-496.
APA Yue, Wen.,Chen, Ziheng.,Liu, Haiyang.,Yan, Chen.,Chen, Ming.,...&Chen, Quan.(2014).A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.CELL RESEARCH,24(4),482-496.
MLA Yue, Wen,et al."A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30".CELL RESEARCH 24.4(2014):482-496.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Yue-2014-A small nat(1659KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yue, Wen]的文章
[Chen, Ziheng]的文章
[Liu, Haiyang]的文章
百度学术
百度学术中相似的文章
[Yue, Wen]的文章
[Chen, Ziheng]的文章
[Liu, Haiyang]的文章
必应学术
必应学术中相似的文章
[Yue, Wen]的文章
[Chen, Ziheng]的文章
[Liu, Haiyang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。