Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus
Huang Sheng-Xiong ; Powell Emily ; Rajski Scott R ; Xu Wei ; Zhao Li-Xing ; Jiang Cheng-Lin ; Duan Yanwen ; Shen Ben*
2010
发表期刊Org. Lett
期号12页码:3525-3527
摘要Estrogen receptor ERr and ER heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutilus (YIM45725) that preferentially induces ERr/ heterodimerization is reported. Total synthesis of 1 has allowed us to determine its absolute stereochemistry and that of a previously known deacetylated congener, and 1 represents the first member of a new class of natural products not previously recognized to modulate ER function.
收录类别SCI
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18021
专题植物化学与西部植物资源持续利用国家重点实验室
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Huang Sheng-Xiong,Powell Emily,Rajski Scott R,et al. Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus[J]. Org. Lett,2010(12):3525-3527.
APA Huang Sheng-Xiong.,Powell Emily.,Rajski Scott R.,Xu Wei.,Zhao Li-Xing.,...&Shen Ben*.(2010).Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus.Org. Lett(12),3525-3527.
MLA Huang Sheng-Xiong,et al."Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus".Org. Lett .12(2010):3525-3527.
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