LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii

doi:10.1021/ol403198d

	LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii
	Geng, Chang-An; Chen, Xing-Long; Zhou, Ning-Jia; Chen, Hao; Ma, Yun-Bao; Huang, Xiao-Yan; Zhang, Xue-Mei; Chen, Ji-Jun
通讯作者	Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; chenjj@mail.kib.ac.cn
	2014-01-17
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	16 期号:2 页码:370-373
摘要	(+/-)-Sweriledugenin A, a pair of novel enantiomeric lactones, were isolated from Swertia leducii under the guidance of LC-MS investigation. The enantiomeric separation was achieved by HPLC on a chiral column. Their structures were determined by extensive NMR spectra, X-ray, and quantum calculations. (+)-Sweriledugenin A and (-)-sweriledugenin A showed activities inhibiting HBV DNA replication with the IC50 values of 36.86 and 26.55 mu M on the HepG 2.2.15 cell line in vitro.
关键词	Alkaloids
学科领域	Chemistry, Organic
DOI	10.1021/ol403198d
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000330098400012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/17945
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Geng, Chang-An,Chen, Xing-Long,Zhou, Ning-Jia,et al. LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii[J]. ORGANIC LETTERS,2014,16(2):370-373.
APA	Geng, Chang-An.,Chen, Xing-Long.,Zhou, Ning-Jia.,Chen, Hao.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2014).LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii.ORGANIC LETTERS,16(2),370-373.
MLA	Geng, Chang-An,et al."LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii".ORGANIC LETTERS 16.2(2014):370-373.

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