LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii
Geng, Chang-An; Chen, Xing-Long; Zhou, Ning-Jia; Chen, Hao; Ma, Yun-Bao; Huang, Xiao-Yan; Zhang, Xue-Mei; Chen, Ji-Jun
2014-01-17
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号16期号:2页码:370-373
摘要(+/-)-Sweriledugenin A, a pair of novel enantiomeric lactones, were isolated from Swertia leducii under the guidance of LC-MS investigation. The enantiomeric separation was achieved by HPLC on a chiral column. Their structures were determined by extensive NMR spectra, X-ray, and quantum calculations. (+)-Sweriledugenin A and (-)-sweriledugenin A showed activities inhibiting HBV DNA replication with the IC50 values of 36.86 and 26.55 mu M on the HepG 2.2.15 cell line in vitro.
关键词Alkaloids
资助信息National Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of China and Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science in Sweden [F/5202-1]; Youth Innovation Promotion Association, CAS
学科领域Chemistry, Organic
DOI10.1021/ol403198d
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000330098400012
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17945
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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GB/T 7714
Geng, Chang-An,Chen, Xing-Long,Zhou, Ning-Jia,et al. LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii[J]. ORGANIC LETTERS,2014,16(2):370-373.
APA Geng, Chang-An.,Chen, Xing-Long.,Zhou, Ning-Jia.,Chen, Hao.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2014).LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii.ORGANIC LETTERS,16(2),370-373.
MLA Geng, Chang-An,et al."LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii".ORGANIC LETTERS 16.2(2014):370-373.
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