Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines
Bai, Bing1,2; Li, Xing-Yao3; Liu, Li1; Li, Yan3; Zhu, Hua-Jie1,3
Corresponding AuthorLi,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; hjzhu@mail.kib.ac.cn
2014
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume24Issue:1Pages:96-98
AbstractA series of beta-carbolines possessing the aryl group at C-1 position has been synthesized from tryptophan. The newly synthesized compounds were screened for their in vitro anticancer activity against various human cancer cell lines by MTT assay. Some of them exhibited anticancer activity with IC50 values lower than 10 mu M outdistanced the cisplatin level. Structure-activity relationship reveals that the alcohol substituents at C-3 position played an important role in inhibition activity. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordBeta-carbolines Cytotoxic Activity Structure-activity Relationship Mtt
Subject AreaChemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2013.11.076
Indexed BySCI ; IC
Language英语
WOS IDWOS:000329114200014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17939
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Hebei Univ, Dept Chem & Chem Engn, Chinese Ctr Chiral, Key Lab Med Chem & Mol Diagnost, Baoding 071002, Peoples R China
2.Zhengzhou Univ Light Ind, Sch Food & Biol Engn, Zhengzhou 450002, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Bai, Bing,Li, Xing-Yao,Liu, Li,et al. Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(1):96-98.
APA Bai, Bing,Li, Xing-Yao,Liu, Li,Li, Yan,&Zhu, Hua-Jie.(2014).Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(1),96-98.
MLA Bai, Bing,et al."Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.1(2014):96-98.
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