Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines

doi:10.1016/j.bmcl.2013.11.076

	Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines
	Bai, Bing 1,2; Li, Xing-Yao 3; Liu, Li1 ; Li, Yan3 ; Zhu, Hua-Jie 1,3
通讯作者	Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; hjzhu@mail.kib.ac.cn
	2014
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	24 期号:1 页码:96-98
摘要	A series of beta-carbolines possessing the aryl group at C-1 position has been synthesized from tryptophan. The newly synthesized compounds were screened for their in vitro anticancer activity against various human cancer cell lines by MTT assay. Some of them exhibited anticancer activity with IC50 values lower than 10 mu M outdistanced the cisplatin level. Structure-activity relationship reveals that the alcohol substituents at C-3 position played an important role in inhibition activity. (C) 2013 Elsevier Ltd. All rights reserved.
关键词	Beta-carbolines Cytotoxic Activity Structure-activity Relationship Mtt
学科领域	Chemistry, Medicinal ; Chemistry, Organic
DOI	10.1016/j.bmcl.2013.11.076
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000329114200014
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/17939
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Hebei Univ, Dept Chem & Chem Engn, Chinese Ctr Chiral, Key Lab Med Chem & Mol Diagnost, Baoding 071002, Peoples R China 2.Zhengzhou Univ Light Ind, Sch Food & Biol Engn, Zhengzhou 450002, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Bai, Bing,Li, Xing-Yao,Liu, Li,et al. Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(1):96-98.
APA	Bai, Bing,Li, Xing-Yao,Liu, Li,Li, Yan,&Zhu, Hua-Jie.(2014).Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(1),96-98.
MLA	Bai, Bing,et al."Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.1(2014):96-98.

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