Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines
Bai, Bing1,2; Li, Xing-Yao3; Liu, Li1; Li, Yan3; Zhu, Hua-Jie1,3
2014
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号24期号:1页码:96-98
摘要A series of beta-carbolines possessing the aryl group at C-1 position has been synthesized from tryptophan. The newly synthesized compounds were screened for their in vitro anticancer activity against various human cancer cell lines by MTT assay. Some of them exhibited anticancer activity with IC50 values lower than 10 mu M outdistanced the cisplatin level. Structure-activity relationship reveals that the alcohol substituents at C-3 position played an important role in inhibition activity. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Beta-carbolines Cytotoxic Activity Structure-activity Relationship Mtt
资助信息Hebei University; Yunnan Province [2009CI120]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2013.11.076
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000329114200014
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17939
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Hebei Univ, Dept Chem & Chem Engn, Chinese Ctr Chiral, Key Lab Med Chem & Mol Diagnost, Baoding 071002, Peoples R China
2.Zhengzhou Univ Light Ind, Sch Food & Biol Engn, Zhengzhou 450002, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Bai, Bing,Li, Xing-Yao,Liu, Li,et al. Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(1):96-98.
APA Bai, Bing,Li, Xing-Yao,Liu, Li,Li, Yan,&Zhu, Hua-Jie.(2014).Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(1),96-98.
MLA Bai, Bing,et al."Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.1(2014):96-98.
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