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题名: Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines
作者: Bai, Bing1, 2; Li, Xing-Yao3; Liu, Li1; null(李艳)3; Zhu, Hua-Jie1, 3
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: beta-Carbolines ; Cytotoxic activity ; Structure-activity relationship ; MTT
英文摘要: A series of beta-carbolines possessing the aryl group at C-1 position has been synthesized from tryptophan. The newly synthesized compounds were screened for their in vitro anticancer activity against various human cancer cell lines by MTT assay. Some of them exhibited anticancer activity with IC50 values lower than 10 mu M outdistanced the cisplatin level. Structure-activity relationship reveals that the alcohol substituents at C-3 position played an important role in inhibition activity. (C) 2013 Elsevier Ltd. All rights reserved.
出版日期: 2014
卷号: 24, 期号:1, 页码:96-98
DOI标识: 10.1016/j.bmcl.2013.11.076
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry, Medicinal ; Chemistry, Organic
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17939
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Hebei Univ, Dept Chem & Chem Engn, Chinese Ctr Chiral, Key Lab Med Chem & Mol Diagnost, Baoding 071002, Peoples R China
2.Zhengzhou Univ Light Ind, Sch Food & Biol Engn, Zhengzhou 450002, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

Recommended Citation:
Bai,Bing;Li,XingYao;Liu,Li;Li,Yan*;Zhu,HuaJie.Syntheses of novel beta-carboline derivatives and the activities against five tumor-cell lines,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(1):96-98
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