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题名: Palladium-Catalyzed Unactivated C(sp(3))-H Bond Activation and intramolecular Amination of Carboxamides: A New Approach to beta-Lactams
作者: Sun, Wen-Wu1, 2; Cao, Pei1; Mei, Ren-Qiang1; Li, Yue1; Ma, Yuan-Liang1; Wu, Bin1
刊名: ORGANIC LETTERS
关键词: C-H ACTIVATION ; CARBON-HYDROGEN BONDS ; SIDE-CHAIN SAR ; ACID DERIVATIVES ; DIRECTING GROUP ; ARYLATION ; FUNCTIONALIZATION ; INHIBITORS ; GAMMA ; CONSTRUCTION
英文摘要: An efficient method to synthesize the beta-lactams with high regioselectivity via Pd-catalyzed C(sp(3))-H bond activation and intramolecular arnination of simple and readily available aminoquinoline carboxamides was demonstrated. C6F5I plays a significant role in the formation of the C-N bond of the four-membered ring beta-lactams. High yield along with wide substrate scope and functional group tolerance makes this reaction applicable to build natural-product-derived beta-lactams. This method has been applied to the efficient synthesis of the beta-lactamase inhibitor MK-8712.
出版日期: 2014-01-17
卷号: 16, 期号:2, 页码:480-483
语种: 英语
收录类别: SCI ; IC ; CCR
学科分类: Chemistry, Organic
ISSN号: 1523-7060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17931
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Sun,WenWu;Cao,Pei;Mei,RenQiang;Li,Yue;Ma,YuanLiang;Wu,Bin*.Palladium-Catalyzed Unactivated C(sp(3))-H Bond Activation and intramolecular Amination of Carboxamides: A New Approach to beta-Lactams,ORGANIC LETTERS,2014,16(2):480-483
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