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题名: Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole
作者: Wan, Wei-Chao1; Chen, Wen1; Liu, Lan-Xiang1; null(李艳)2; Yang, Li-Juan3, 4; Deng, Xiao-Yan1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
刊名: MEDICINAL CHEMISTRY RESEARCH
关键词: Hybrid compound ; Benzofuran ; Imidazole ; Cytotoxic activity ; Structure-activity relationships ; Molecular docking
英文摘要: A series of novel hybrid compounds between 2-alkylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of 2-methyl-imidazole or 2-ethyl-imidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or methoxyphenacyl group were vital for modulating cytotoxic activity. In particular, hybrid compound 29 was found to be the most potent compound against five strains human tumor cell lines and more active than cisplatin (DDP), while hybrid compound 26 was more selective toward colon carcinoma (SW480) and breast carcinoma (MCF-7) with IC50 value 44.0- and 36.8-fold more sensitive to DDP.
出版日期: 2014-03-01
卷号: 23, 期号:3, 页码:1599-1611
DOI标识: 10.1007/s00044-013-0760-8
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal
ISSN号: 1054-2523
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17928
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
4.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China

Recommended Citation:
Wan,WeiChao;Chen,Wen;Liu,LanXiang;Li,Yan;Yang,LiJuan;Deng,XiaoYan;Zhang,HongBin;Yang,XiaoDong*.Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole,MEDICINAL CHEMISTRY RESEARCH,2014,23(3):1599-1611
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