Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole
Wan, Wei-Chao1; Chen, Wen1; Liu, Lan-Xiang1; Li, Yan2; Yang, Li-Juan3,4; Deng, Xiao-Yan1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
2014-03-01
发表期刊MEDICINAL CHEMISTRY RESEARCH
ISSN1054-2523
卷号23期号:3页码:1599-1611
摘要A series of novel hybrid compounds between 2-alkylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of 2-methyl-imidazole or 2-ethyl-imidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or methoxyphenacyl group were vital for modulating cytotoxic activity. In particular, hybrid compound 29 was found to be the most potent compound against five strains human tumor cell lines and more active than cisplatin (DDP), while hybrid compound 26 was more selective toward colon carcinoma (SW480) and breast carcinoma (MCF-7) with IC50 value 44.0- and 36.8-fold more sensitive to DDP.
关键词Hybrid Compound Benzofuran Imidazole Cytotoxic Activity Structure-activity Relationships Molecular Docking
资助信息NSFC [30960460, 20925205, 21062026]; NSFYN [2010GA014, 2012FB113]; Project of Recruited Top Talent of Sciences and Technology of Yunnan Province [2009C1120]; National Basic Research Program of China (973 Program) [2009CB522300]
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17928
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
4.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
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Wan, Wei-Chao,Chen, Wen,Liu, Lan-Xiang,et al. Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole[J]. MEDICINAL CHEMISTRY RESEARCH,2014,23(3):1599-1611.
APA Wan, Wei-Chao.,Chen, Wen.,Liu, Lan-Xiang.,Li, Yan.,Yang, Li-Juan.,...&Yang, Xiao-Dong.(2014).Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole.MEDICINAL CHEMISTRY RESEARCH,23(3),1599-1611.
MLA Wan, Wei-Chao,et al."Synthesis and cytotoxic activity of novel hybrid compounds between 2-alkylbenzofuran and imidazole".MEDICINAL CHEMISTRY RESEARCH 23.3(2014):1599-1611.
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