Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia

doi:10.1021/np4005823

	Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia
	Fu, Yan-hui1,2 ; Di, Ying-tong1 ; He, Hong-ping 1; Li, Shun-lin 1; Zhang, Yu1 ; Hao, Xiao-jiang1
通讯作者	Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
	2014
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	77 期号:1 页码:57-62
摘要	Two new bisindole alkaloids, angustifonines A (1) and B (2), comprising the union of a rearranged monoterpenoid quinoline and an aspidospermine alkaloid, as well as 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia angustifolia. Their structures and absolute configurations were elucidated by a combination of MS, NMR, and computational methods. Angustifonines A and B exhibited cytotoxicity against various human cancer cell lines with IC50 values of 2.71-16.22 mu M. A possible biosynthesis pathway toward the new bisindole alkaloids 1 and 2 is presented.
关键词	Magnetic-resonance-spectroscopy Naturally-occurring Substances Aspidospermane-type Alkaloids Catharanthus-roseus Melodinus-suaveolens Hunteria-eburnea Indole Alkaloids Vinca Alkaloids New-caledonia Plants
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np4005823
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000330336800010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/17926
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,et al. Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(1):57-62.
APA	Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,Li, Shun-lin,Zhang, Yu,&Hao, Xiao-jiang.(2014).Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia.JOURNAL OF NATURAL PRODUCTS,77(1),57-62.
MLA	Fu, Yan-hui,et al."Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia".JOURNAL OF NATURAL PRODUCTS 77.1(2014):57-62.

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