Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia
Fu, Yan-hui1,2; Di, Ying-tong1; He, Hong-ping1; Li, Shun-lin1; Zhang, Yu1; Hao, Xiao-jiang1
Corresponding AuthorZhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
2014
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume77Issue:1Pages:57-62
AbstractTwo new bisindole alkaloids, angustifonines A (1) and B (2), comprising the union of a rearranged monoterpenoid quinoline and an aspidospermine alkaloid, as well as 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia angustifolia. Their structures and absolute configurations were elucidated by a combination of MS, NMR, and computational methods. Angustifonines A and B exhibited cytotoxicity against various human cancer cell lines with IC50 values of 2.71-16.22 mu M. A possible biosynthesis pathway toward the new bisindole alkaloids 1 and 2 is presented.
KeywordMagnetic-resonance-spectroscopy Naturally-occurring Substances Aspidospermane-type Alkaloids Catharanthus-roseus Melodinus-suaveolens Hunteria-eburnea Indole Alkaloids Vinca Alkaloids New-caledonia Plants
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np4005823
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000330336800010
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17926
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,et al. Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(1):57-62.
APA Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,Li, Shun-lin,Zhang, Yu,&Hao, Xiao-jiang.(2014).Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia.JOURNAL OF NATURAL PRODUCTS,77(1),57-62.
MLA Fu, Yan-hui,et al."Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia".JOURNAL OF NATURAL PRODUCTS 77.1(2014):57-62.
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