Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia
Fu, Yan-hui1,2; Di, Ying-tong1; He, Hong-ping1; Li, Shun-lin1; Zhang, Yu1; Hao, Xiao-jiang1
2014
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号77期号:1页码:57-62
摘要Two new bisindole alkaloids, angustifonines A (1) and B (2), comprising the union of a rearranged monoterpenoid quinoline and an aspidospermine alkaloid, as well as 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia angustifolia. Their structures and absolute configurations were elucidated by a combination of MS, NMR, and computational methods. Angustifonines A and B exhibited cytotoxicity against various human cancer cell lines with IC50 values of 2.71-16.22 mu M. A possible biosynthesis pathway toward the new bisindole alkaloids 1 and 2 is presented.
关键词Magnetic-resonance-spectroscopy Naturally-occurring Substances Aspidospermane-type Alkaloids Catharanthus-roseus Melodinus-suaveolens Hunteria-eburnea Indole Alkaloids Vinca Alkaloids New-caledonia Plants
资助信息National Natural Science Foundation of China [31100259]; National Basic Research Program of China [2009CB522303]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np4005823
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000330336800010
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17926
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,et al. Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(1):57-62.
APA Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,Li, Shun-lin,Zhang, Yu,&Hao, Xiao-jiang.(2014).Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia.JOURNAL OF NATURAL PRODUCTS,77(1),57-62.
MLA Fu, Yan-hui,et al."Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia".JOURNAL OF NATURAL PRODUCTS 77.1(2014):57-62.
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