Chemical constituents from Aphanamixis grandifolia
Zhang, Rong1,2; He, Hong-Ping1; Di, Ying-Tong1; Li, Shun-Lin1; Zuo, Guo-Ying3; Zhang, Yu1; Hao, Xiao-Jiang1
2014
发表期刊FITOTERAPIA
ISSN0367-326X
卷号92页码:100-104
摘要Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with delta-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic diterpenoids, which are structurally related nemoralisin C and nemoralisin. These structures were established on the basis of spectroscopic methods and the absolute configuration of 1 was determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Nemoralisins D-G (1-4) were tested for their cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines (IC50 > 40 mu M), as well as the antimicrobial activities on Staphylococcus aureus, Pseudomonas aeruginosa, MRSA92(#) and MRSA98(#) (MIC > 50 mu g/mL). (C) 2013 Elsevier B.V. All rights reserved.
关键词Aphanamixis Grandifolia Diterpenoid Tddft Nemoralisins D-g
资助信息National Basic Research Program of China [2009CB522303]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2013.10.014
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000331420300013
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17925
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Chengdu Mil Command, Kunming Gen Hosp, Sch Clin, Res Ctr Nat Med, Kunming 650032, Peoples R China
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Zhang, Rong,He, Hong-Ping,Di, Ying-Tong,et al. Chemical constituents from Aphanamixis grandifolia[J]. FITOTERAPIA,2014,92:100-104.
APA Zhang, Rong.,He, Hong-Ping.,Di, Ying-Tong.,Li, Shun-Lin.,Zuo, Guo-Ying.,...&Hao, Xiao-Jiang.(2014).Chemical constituents from Aphanamixis grandifolia.FITOTERAPIA,92,100-104.
MLA Zhang, Rong,et al."Chemical constituents from Aphanamixis grandifolia".FITOTERAPIA 92(2014):100-104.
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