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题名: Natural inhibitors of DNA topoisomerase I with cytotoxicities
作者: Hong-Jin Han; Ning-Hua Tan; Guang-Zhi Zeng; Jun-Ting Fan; Huo-Qiang Huang; Chang-Jiu Ji; Rui-Rui Jia; Qin-Shi Zhao; Ying-Jun Zhang; Xiao-Jiang Hao; Li-Qin Wang
刊名: CHEMISTRY & BIODIVERSITY
关键词: SALVIA-MILTIORRHIZA BUNGE ; CAMPTOTHECIN ; DITERPENOIDS ; FLAVONES
英文摘要: DNA Topoisomerase I can cause DNA breaks and play a key role during cell proliferation and differentiation. It is an important target for anticancer agents. While screening for anticancer compounds, seven natural compounds, 1-7, showed potent cytotoxicities against a panel of ten cancer cell lines. Moreover, an inhibition assay demonstrated that they are also DNA topoisomerase I inhibitors, in which inhibitors 1-5 are new ones.
出版日期: 2008
卷号: 5, 期号:7, 页码:1364-1368
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Chemistry; Multidisciplinary
ISSN号: 1612-1872
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1787
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Recommended Citation:
Han, HJ; Tan, NH; Zeng, GZ; Fan, JT; Huang, HQ; Ji, CJ; Jia, RR; Zhao, QS; Zhang, YJ; Hao, XJ; Wang, LQ.Natural inhibitors of DNA topoisomerase I with cytotoxicities,CHEMISTRY & BIODIVERSITY,2008,5(7):1364-1368
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文件名: Natural Inhibitors of DNA Topoisomerase I with Cytotoxicities.pdf
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