Natural inhibitors of DNA topoisomerase I with cytotoxicities
Hong-Jin Han; Ning-Hua Tan; Guang-Zhi Zeng; Jun-Ting Fan; Huo-Qiang Huang; Chang-Jiu Ji; Rui-Rui Jia; Qin-Shi Zhao; Ying-Jun Zhang; Xiao-Jiang Hao; Li-Qin Wang
2008
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Volume5Issue:7Pages:1364-1368
Abstract

DNA Topoisomerase I can cause DNA breaks and play a key role during cell proliferation and differentiation. It is an important target for anticancer agents. While screening for anticancer compounds, seven natural compounds, 1-7, showed potent cytotoxicities against a panel of ten cancer cell lines. Moreover, an inhibition assay demonstrated that they are also DNA topoisomerase I inhibitors, in which inhibitors 1-5 are new ones.

KeywordSalvia-miltiorrhiza Bunge Camptothecin Diterpenoids Flavones
Subject AreaBiochemistry & Molecular Biology ; Chemistry ; Multidisciplinary
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000258089900015
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1787
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Hong-Jin Han,Ning-Hua Tan,Guang-Zhi Zeng,et al. Natural inhibitors of DNA topoisomerase I with cytotoxicities[J]. CHEMISTRY & BIODIVERSITY,2008,5(7):1364-1368.
APA Hong-Jin Han.,Ning-Hua Tan.,Guang-Zhi Zeng.,Jun-Ting Fan.,Huo-Qiang Huang.,...&Li-Qin Wang.(2008).Natural inhibitors of DNA topoisomerase I with cytotoxicities.CHEMISTRY & BIODIVERSITY,5(7),1364-1368.
MLA Hong-Jin Han,et al."Natural inhibitors of DNA topoisomerase I with cytotoxicities".CHEMISTRY & BIODIVERSITY 5.7(2008):1364-1368.
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