Both Stress Experience and Age Determined the Impairment or Enhancement Effect of Stress on Spatial Memory Retrieval
Yuexiong Yang ; Jun Cao ; Wenyong Xiong ; Jichuan Zhang ; Qixin Zhou ; Huiming Wei ; Chongli Liang ; Jianhua Deng ; Tianfei Li ; Shangchuan Yang ; Lin Xu
2003
Source PublicationJournal of Endocrinology
Volume178Issue:1Pages:45-54
AbstractIt has been documented that stress or glucocorticoids have conflicting effects on memory under different conditions. However, it is not fully understood why stress can either impair or enhance memory. Here, we have examined the performance of six age groups of Wistar rats in a water maze spatial task to evaluate the effects of stress under different conditions. We found that the impairment or enhancement effect of an 'elevated platform' (EP) stress on memory was dependent on previous stress experience and on age. EP stress impaired memory retrieval in water maze naive animals, but enhanced rather than impaired memory retrieval in young water maze stress-experienced animals. Furthermore, exogenously applied corticosterone or foot shock stress before water maze training prevented the impairment of memory retrieval that should be induced by treatment with corticosterone or foot shock before the 'probe trial'. Again, memory retrieval was enhanced in young animals under these conditions, and this enhancement can be prevented by the glucocorticoid receptor antagonist RU 38486. Thus, glucocorticoid receptor activation not only induced impairment of memory but also increased the capacity of young animals to overcome a later stress. The present findings suggest that the effect of stress on memory can be switched from impairment to enhancement dependent on both stress experience and age.
Indexed BySCI
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17717
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Yuexiong Yang,Jun Cao,Wenyong Xiong,et al. Both Stress Experience and Age Determined the Impairment or Enhancement Effect of Stress on Spatial Memory Retrieval[J]. Journal of Endocrinology,2003,178(1):45-54.
APA Yuexiong Yang.,Jun Cao.,Wenyong Xiong.,Jichuan Zhang.,Qixin Zhou.,...&Lin Xu.(2003).Both Stress Experience and Age Determined the Impairment or Enhancement Effect of Stress on Spatial Memory Retrieval.Journal of Endocrinology,178(1),45-54.
MLA Yuexiong Yang,et al."Both Stress Experience and Age Determined the Impairment or Enhancement Effect of Stress on Spatial Memory Retrieval".Journal of Endocrinology 178.1(2003):45-54.
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