Mechanisms of Peptide Hormone Secretion

	Mechanisms of Peptide Hormone Secretion
	Darren J Michael ; Haijiang Cai ; Wenyong Xiong ; Justin Ouyang ; Robert H Chow
通讯作者	Robert H Chow
	2006
发表期刊	Trends in Endocrinology and Metabolism
卷号	17 期号:10 页码:408-415
摘要	According to the classical view, peptide hormones are stored in large dense-core vesicles that release all of their cargo rapidly and completely when they fuse with and flatten into the plasma membrane. However, recent imaging studies suggest that this view is too simple. Even after vesicles fuse with the plasma membrane, cells might control the rate of dispersal of vesicle cargo – either by modulating the properties of the fusion pore that connects the vesicle lumen to the extracellular solution or by storing cargo in states that disperse slowly in the extracellular space. Understanding these mechanisms is important, owing to the increasing prevalence of diseases, such as type 2 diabetes mellitus, which arise from insufficient secretion of peptide hormones.
收录类别	SCI
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/17708
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Darren J Michael,Haijiang Cai,Wenyong Xiong,et al. Mechanisms of Peptide Hormone Secretion[J]. Trends in Endocrinology and Metabolism,2006,17(10):408-415.
APA	Darren J Michael,Haijiang Cai,Wenyong Xiong,Justin Ouyang,&Robert H Chow.(2006).Mechanisms of Peptide Hormone Secretion.Trends in Endocrinology and Metabolism,17(10),408-415.
MLA	Darren J Michael,et al."Mechanisms of Peptide Hormone Secretion".Trends in Endocrinology and Metabolism 17.10(2006):408-415.

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