| Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia | |
He, Kang1,2; Ma, Yun-Bao1; Cao, Tuan-Wu1,2; Wang, Hong-Ling1,2; Jiang, Fu-Qiang1; Geng, Chang-An1 ; Zhang, Xue-Mei1; Chen, Ji-Jun1
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| 通讯作者 | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 Lanhei Rd, Kunming 650201, Peoples R China,chenjj@mail.kib.ac.cn |
| 2012-05-01 | |
| 发表期刊 | PLANTA MEDICA
 |
| ISSN | 0032-0943 |
| 卷号 | 78期号:8页码:814-820 |
| 摘要 | Seven new secoiridoids, swertianglide (1) and swertianosides A-F (2-7), together with fifteen known compounds, were isolated from the whole plants of Swertia angustifolia. Their structures were elucidated on the basis of extensive spectroscopic analyses ([alpha](D), UV, IR, MS, 1D- and 2D-NMR). Fourteen compounds were evaluated for their anti-hepatitis B virus (HBV) activities on the Hep G 2.2.15 cell line in vitro. Compound 2, an unusual secoiridoid glycoside dimer, showed significant activities inhibiting the secretion of HBsAg (IC50 0.18 mM, SI 3.11) and HBeAg (IC50 0.12 mM, SI 4.67). |
| 关键词 | Secoiridoids Swertianglide Swertianosides A-f Swertia Angustifolia Gentianaceae Anti-hbv Activity |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1055/s-0031-1298381 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304449300012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17623 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Kang,Ma, Yun-Bao,Cao, Tuan-Wu,et al. Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia[J]. PLANTA MEDICA,2012,78(8):814-820. |
| APA | He, Kang.,Ma, Yun-Bao.,Cao, Tuan-Wu.,Wang, Hong-Ling.,Jiang, Fu-Qiang.,...&Chen, Ji-Jun.(2012).Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia.PLANTA MEDICA,78(8),814-820. |
| MLA | He, Kang,et al."Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia".PLANTA MEDICA 78.8(2012):814-820. |
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