Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia

doi:10.1055/s-0031-1298381

	Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia
	He, Kang 1,2; Ma, Yun-Bao 1; Cao, Tuan-Wu 1,2; Wang, Hong-Ling 1,2; Jiang, Fu-Qiang 1; Geng, Chang-An1 ; Zhang, Xue-Mei1 ; Chen, Ji-Jun1
通讯作者	Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 Lanhei Rd, Kunming 650201, Peoples R China,chenjj@mail.kib.ac.cn
	2012-05-01
发表期刊	PLANTA MEDICA
ISSN	0032-0943
卷号	78 期号:8 页码:814-820
摘要	Seven new secoiridoids, swertianglide (1) and swertianosides A-F (2-7), together with fifteen known compounds, were isolated from the whole plants of Swertia angustifolia. Their structures were elucidated on the basis of extensive spectroscopic analyses ([alpha](D), UV, IR, MS, 1D- and 2D-NMR). Fourteen compounds were evaluated for their anti-hepatitis B virus (HBV) activities on the Hep G 2.2.15 cell line in vitro. Compound 2, an unusual secoiridoid glycoside dimer, showed significant activities inhibiting the secretion of HBsAg (IC50 0.18 mM, SI 3.11) and HBeAg (IC50 0.12 mM, SI 4.67).
关键词	Secoiridoids Swertianglide Swertianosides A-f Swertia Angustifolia Gentianaceae Anti-hbv Activity
学科领域	Plant Sciences ; Pharmacology & Pharmacy
DOI	10.1055/s-0031-1298381
收录类别	SCI
语种	英语
WOS记录号	WOS:000304449300012
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/17623
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
推荐引用方式 GB/T 7714	He, Kang,Ma, Yun-Bao,Cao, Tuan-Wu,et al. Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia[J]. PLANTA MEDICA,2012,78(8):814-820.
APA	He, Kang.,Ma, Yun-Bao.,Cao, Tuan-Wu.,Wang, Hong-Ling.,Jiang, Fu-Qiang.,...&Chen, Ji-Jun.(2012).Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia.PLANTA MEDICA,78(8),814-820.
MLA	He, Kang,et al."Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia".PLANTA MEDICA 78.8(2012):814-820.

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