Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia
He, Kang1,2; Ma, Yun-Bao1; Cao, Tuan-Wu1,2; Wang, Hong-Ling1,2; Jiang, Fu-Qiang1; Geng, Chang-An1; Zhang, Xue-Mei1; Chen, Ji-Jun1
2012-05-01
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号78期号:8页码:814-820
摘要Seven new secoiridoids, swertianglide (1) and swertianosides A-F (2-7), together with fifteen known compounds, were isolated from the whole plants of Swertia angustifolia. Their structures were elucidated on the basis of extensive spectroscopic analyses ([alpha](D), UV, IR, MS, 1D- and 2D-NMR). Fourteen compounds were evaluated for their anti-hepatitis B virus (HBV) activities on the Hep G 2.2.15 cell line in vitro. Compound 2, an unusual secoiridoid glycoside dimer, showed significant activities inhibiting the secretion of HBsAg (IC50 0.18 mM, SI 3.11) and HBeAg (IC50 0.12 mM, SI 4.67).
关键词Secoiridoids Swertianglide Swertianosides A-f Swertia Angustifolia Gentianaceae Anti-hbv Activity
资助信息We are thankful for the financial support from the National Natural Sciences Foundation of China for Distinguished Young Scholars (No. 81025023), National Natural Science Foundation of China and Yunan Province (Grant No. U0832603), and Major Project of Innovative Engineering (KSCX2-YW-R-181), and are also grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0031-1298381
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000304449300012
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17623
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
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He, Kang,Ma, Yun-Bao,Cao, Tuan-Wu,et al. Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia[J]. PLANTA MEDICA,2012,78(8):814-820.
APA He, Kang.,Ma, Yun-Bao.,Cao, Tuan-Wu.,Wang, Hong-Ling.,Jiang, Fu-Qiang.,...&Chen, Ji-Jun.(2012).Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia.PLANTA MEDICA,78(8),814-820.
MLA He, Kang,et al."Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia".PLANTA MEDICA 78.8(2012):814-820.
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