Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia
He, Kang1,2; Ma, Yun-Bao1; Cao, Tuan-Wu1,2; Wang, Hong-Ling1,2; Jiang, Fu-Qiang1; Geng, Chang-An1; Zhang, Xue-Mei1; Chen, Ji-Jun1
Corresponding AuthorChen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, 132 Lanhei Rd, Kunming 650201, Peoples R China,chenjj@mail.kib.ac.cn
2012-05-01
Source PublicationPLANTA MEDICA
ISSN0032-0943
Volume78Issue:8Pages:814-820
AbstractSeven new secoiridoids, swertianglide (1) and swertianosides A-F (2-7), together with fifteen known compounds, were isolated from the whole plants of Swertia angustifolia. Their structures were elucidated on the basis of extensive spectroscopic analyses ([alpha](D), UV, IR, MS, 1D- and 2D-NMR). Fourteen compounds were evaluated for their anti-hepatitis B virus (HBV) activities on the Hep G 2.2.15 cell line in vitro. Compound 2, an unusual secoiridoid glycoside dimer, showed significant activities inhibiting the secretion of HBsAg (IC50 0.18 mM, SI 3.11) and HBeAg (IC50 0.12 mM, SI 4.67).
KeywordSecoiridoids Swertianglide Swertianosides A-f Swertia Angustifolia Gentianaceae Anti-hbv Activity
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
DOI10.1055/s-0031-1298381
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000304449300012
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17623
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
Recommended Citation
GB/T 7714
He, Kang,Ma, Yun-Bao,Cao, Tuan-Wu,et al. Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia[J]. PLANTA MEDICA,2012,78(8):814-820.
APA He, Kang.,Ma, Yun-Bao.,Cao, Tuan-Wu.,Wang, Hong-Ling.,Jiang, Fu-Qiang.,...&Chen, Ji-Jun.(2012).Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia.PLANTA MEDICA,78(8),814-820.
MLA He, Kang,et al."Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia".PLANTA MEDICA 78.8(2012):814-820.
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