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题名: Cytotoxicity and Antimicrobial Activity of the Methanol Extract and Compounds from Polygonum limbatum
作者: Dzoyem, Jean P.1; NKuete, Antoine H. L.2; Kuete, Victor1; Tala, Michel F.2; Wabo, Hippolyte K.2; Guru, Santosh K.3; Rajput, Vikrant S.4; Sharma, Akash4; Tane, Pierre2; Khan, Inshad A.4; Saxena, Anil K.4; Laatsch, Hartmut5; Tan, Ning-Hua6
刊名: PLANTA MEDICA
关键词: Polygonum limbatum ; Polygonaceae ; extract ; compounds ; antimicrobial ; cytotoxicity
英文摘要: The present study was designed to investigate the antimicrobial activity and the cytotoxicity of the methanol extract (PLA) as well as fractions (PLA1-4) and compounds [cardamomin (1), (+/-)-polygohomoisoflavanone (2), (S)-(-)-pinostrobin (3), 2',4'-dihydroxy-3',6'-dimethoxychalcone (4), (2S)-(-)-5-hydroxy-6,7-dimethoxyflavanone (5), and (2S)-(-)-5,7-dimethoxyflavanone (6)] obtained from leaves of Polygonum limbatum. The microbroth dilution was used to determine the minimal inhibitory concentration (MIC) of the samples against 11 microbial strains including Candida albicans, C. krusei, C. tropicalis, Aspergillus fumigatus, Pseudomonas aeruginosa, Escherichia coli, vancomycin-resistant Enterococcus faecalis (VRE), Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and Mycobacterium tuberculosis H37Rv. The sulphorhodamine B cell growth inhibition assay was used to assess the cytotoxicity of the above samples on lung A549 adenocarcinoma, breast carcinoma MCF-7, prostate carcinoma PC-3, cervical carcinoma HeLa, and the acute monocytic leukemia cell line THP-1. The results of the MIC determination indicated that, apart from fraction PLA3, all other fractions as well as PLA and compound 3 were selectively active. MIC values were noted on 100% of the 11 tested microorganisms for fraction PLA3, 72.7% for PLA, fraction PLA2, and compound 4, 63.6% for PLA1, and 54.5% for fraction PLA4. The results of the cytotoxicity assay revealed that, except for A459 cells, more than 50% inhibition of the proliferation was obtained with each of the tested samples on at least one of the four other cell lines. IC50 values below 4 mu g/mL were obtained with 1 and 4 on THP-1 cells. The overall results of the present study provided baseline information for the possible use of Polygonum limbatum as well as some of the isolated compounds for the control of cancer diseases and mostly leukemia.
出版日期: 2012-05-01
卷号: 78, 期号:8, 页码:787-792
语种: 英语
收录类别: SCI
学科分类: Plant Sciences ; Pharmacology & Pharmacy
ISSN号: 0032-0943
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17621
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Univ Dschang, Fac Sci, Dept Biochem, Dschang 237, Cameroon
2.Univ Dschang, Fac Sci, Dept Chem, Dschang 237, Cameroon
3.Indian Inst Integrat Med, Canc Pharmacol Div, Cell Signalling Lab, Jammu, India
4.Indian Inst Integrat Med, Clin Microbiol Unit, Jammu, India
5.Univ Gottingen, Inst Organ & Biomol Chem, Gottingen, Germany
6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China
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