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题名: Trigoflavidols A-C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus
作者: Tang, Gui-Hua1, 2; Zhang, Yu1; Gu, Yu-Cheng3; Li, Shi-Fei1, 2; Di, Ying-Tong1; Wang YueHu(王跃虎)4; Yang, Cui-Xian5; Zuo, Guo-Ying5; Li, Shun-Lin1; He, Hong-Ping1; null(郝小江)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: REIDIOIDES ; CHINENSIS ; DAPHNANE ; CONSTITUENTS ; PLANT
英文摘要: Trigoflavidols A (1) and B (2), tetranorditerpenoid dimers possessing a rearrangement skeleton with a spiroketal core moiety, and trigoflavidol C (3), a hexanorditerpenoid, have been isolated from Trigonostemon flavidus along with two known compounds. Compounds 1 and 2 showed moderate antimicrobial activities (MIC values: 3.12-6.25 mu g/mL) against Staphylococcus aureus, 8#MRSA, and 82#MRSA, and 1, 2, and 5 showed weak activities (IC50 values: 3.75-28.99 mu M) against various human tumor cell lines.
出版日期: 2012-05-01
卷号: 75, 期号:5, 页码:996-1000
DOI标识: 10.1021/np3001128
语种: 英语
ISSN号: 0163-3864
资助信息: The Syngenta postgraduate studentship awarded to G.-H.T. (2010-2013, Kunming Institute of Botany, Chinese Academy of Sciences, Syngenta 1) is appreciated. This work was financially supported by the National Natural Science Foundation of China (30830114, 21072199), the National Basic Research Program of China (973 Program, 2009CB522300), the Natural Science Funding of Yunnan Province (2009CD112), the Foundation of Chinese Academy of Sciences to H.P.H, and the Young Academic and Technical Leader Raising Foundation of Yunnan Province (2010CI047, 2009CI072).
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17611
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
4.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
5.Chengdu Mil Command, Kunming Gen Hosp, Sch Clin, Res Ctr Nat Med, Kunming 650032, Peoples R China

Recommended Citation:
Tang,Gui-Hua;Zhang,Yu;Gu,Yu-Cheng;Li,Shi-Fei;Di,Ying-Tong;Wang,Yue-Hu;Yang,Cui-Xian;Zuo,Guo-Ying;Li,Shun-Lin;He,Hong-Ping;Hao,Xiao-Jiang.Trigoflavidols A-C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus,JOURNAL OF NATURAL PRODUCTS,2012,75(5):996-1000
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