Trigoflavidols A-C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus
Tang, Gui-Hua1,2; Zhang, Yu1; Gu, Yu-Cheng3; Li, Shi-Fei1,2; Di, Ying-Tong1; Wang, Yue-Hu4; Yang, Cui-Xian5; Zuo, Guo-Ying5; Li, Shun-Lin1; He, Hong-Ping1; Hao, Xiao-Jiang1
2012-05-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号75期号:5页码:996-1000
摘要Trigoflavidols A (1) and B (2), tetranorditerpenoid dimers possessing a rearrangement skeleton with a spiroketal core moiety, and trigoflavidol C (3), a hexanorditerpenoid, have been isolated from Trigonostemon flavidus along with two known compounds. Compounds 1 and 2 showed moderate antimicrobial activities (MIC values: 3.12-6.25 mu g/mL) against Staphylococcus aureus, 8#MRSA, and 82#MRSA, and 1, 2, and 5 showed weak activities (IC50 values: 3.75-28.99 mu M) against various human tumor cell lines.
关键词Reidioides Chinensis Daphnane Constituents Plant
资助信息The Syngenta postgraduate studentship awarded to G.-H.T. (2010-2013, Kunming Institute of Botany, Chinese Academy of Sciences, Syngenta 1) is appreciated. This work was financially supported by the National Natural Science Foundation of China (30830114, 21072199), the National Basic Research Program of China (973 Program, 2009CB522300), the Natural Science Funding of Yunnan Province (2009CD112), the Foundation of Chinese Academy of Sciences to H.P.H, and the Young Academic and Technical Leader Raising Foundation of Yunnan Province (2010CI047, 2009CI072).
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np3001128
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000304385800022
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17611
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
4.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
5.Chengdu Mil Command, Kunming Gen Hosp, Sch Clin, Res Ctr Nat Med, Kunming 650032, Peoples R China
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Tang, Gui-Hua,Zhang, Yu,Gu, Yu-Cheng,et al. Trigoflavidols A-C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(5):996-1000.
APA Tang, Gui-Hua.,Zhang, Yu.,Gu, Yu-Cheng.,Li, Shi-Fei.,Di, Ying-Tong.,...&Hao, Xiao-Jiang.(2012).Trigoflavidols A-C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus.JOURNAL OF NATURAL PRODUCTS,75(5),996-1000.
MLA Tang, Gui-Hua,et al."Trigoflavidols A-C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus".JOURNAL OF NATURAL PRODUCTS 75.5(2012):996-1000.
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