ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora
Wang Weiguang1,2; Wu Haiyan1; Du Xue1; Yan Juming1; Li Yan1; Pu Jianxin1; Sun Handong1
2012-06-01
发表期刊CHINESE JOURNAL OF CHEMISTRY
ISSN1001-604X
卷号30期号:6页码:1226-1230
摘要Four new ent-kaurane diterpenoids, 6 beta,13a,15 beta-trihydroxy-16-ene-3a,20-epoxy-ent-kaur-1,7-dione (1), 6-hydroxy-3a,20-epoxy-5(6)-ene-ent-kaur-1,7,15-trione (2), 6-hydroxy-15 beta-acetoxy-3a,20-epoxy-16 beta,17-epoxy-5(6)-ene-ent-kaur-1,7-dione (3), 3a,17-dihydroxy-15(16)-ene-ent-kaur-7-one (4), along with four known compounds 58 were isolated from the leaves of Isodon eriocalyx var. laxiflora. The structures were elucidated by extensive spectroscopic methods (IR, UV, MS and NMR). The cytotoxic activities of these compounds were evaluated by MTT assay. Compound 8 showed moderate inhibitory effects on HL-60, SMMC-7721, MCF-7 and SW-480 cell lines.
关键词Ent-kaurane Diterpenoid Isodon Structure Elucidation Cytotoxicity
资助信息This project was supported financially by the NSFC-Joint Foundation of Yunnan Province (No. U0832602 to H.-D. Sun), the National Natural Science Foundation of China (No. 81172939 to J.-X. Pu), the Major State Basic Research Development Program of China (Nos. 2009CB522300 and 2009CB940900), the Science and Technology Program of Yunan Province (Nos. 2008IF010 and 2008CD162), and the Major Direction Projection Foundation of CAS Intellectual Innovation Project (No. 2010KIBA05 to J.-X. Pu).
学科领域Chemistry
DOI10.1002/cjoc.201100653
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000305389200005
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17608
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Kunming 650201, Yunan, Peoples R China
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Wang Weiguang,Wu Haiyan,Du Xue,et al. ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora[J]. CHINESE JOURNAL OF CHEMISTRY,2012,30(6):1226-1230.
APA Wang Weiguang.,Wu Haiyan.,Du Xue.,Yan Juming.,Li Yan.,...&Sun Handong.(2012).ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora.CHINESE JOURNAL OF CHEMISTRY,30(6),1226-1230.
MLA Wang Weiguang,et al."ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora".CHINESE JOURNAL OF CHEMISTRY 30.6(2012):1226-1230.
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