| Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation | |
Yan, Yong-Ming1,2; Wu, Gui-Sheng1 ; Dong, Xiao-Ping2; Shen, Lan1; Li, Yan1; Su, Jia1; Luo, Huai-Rong1; Zhu, Hua-Jie1; Cheng, Yong-Xian1,2
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| 通讯作者 | Zhu, HJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China,hjzhu@mail.kib.ac.cn ; yxcheng@mail.kib.ac.cn |
| 2012-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 75期号:6页码:1025-1029 |
| 摘要 | Diincarvilones A-D (1-4), incarvilone A (5), and a known compound, argutosine B (6), were isolated from Incarvillea arguia. The structures, including the absolute configurations of the new compounds, were determined by NMR spectroscopy, X-ray diffraction analysis, CD spectroscopy, and a variety of computational methods. The biological properties of these substances, including effects on intracellular Ca2+ influx, nitric oxide (NO) production, and human cancer cells, were evaluated. The results showed that at the concentration of 10 mu M (in HBSS buffer) diincarvilones A and B cause a persistent increase in cytoplasmic calcium levels in A549 cells. |
| 关键词 | Electronic Circular-dichroism Optical-rotation Chemistry Assay |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np200912p |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000305503500003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17604 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Yong-Ming,Wu, Gui-Sheng,Dong, Xiao-Ping,et al. Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(6):1025-1029. |
| APA | Yan, Yong-Ming.,Wu, Gui-Sheng.,Dong, Xiao-Ping.,Shen, Lan.,Li, Yan.,...&Cheng, Yong-Xian.(2012).Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation.JOURNAL OF NATURAL PRODUCTS,75(6),1025-1029. |
| MLA | Yan, Yong-Ming,et al."Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation".JOURNAL OF NATURAL PRODUCTS 75.6(2012):1025-1029. |
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