Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation
Yan, Yong-Ming1,2; Wu, Gui-Sheng1; Dong, Xiao-Ping2; Shen, Lan1; Li, Yan1; Su, Jia1; Luo, Huai-Rong1; Zhu, Hua-Jie1; Cheng, Yong-Xian1,2
2012-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号75期号:6页码:1025-1029
摘要Diincarvilones A-D (1-4), incarvilone A (5), and a known compound, argutosine B (6), were isolated from Incarvillea arguia. The structures, including the absolute configurations of the new compounds, were determined by NMR spectroscopy, X-ray diffraction analysis, CD spectroscopy, and a variety of computational methods. The biological properties of these substances, including effects on intracellular Ca2+ influx, nitric oxide (NO) production, and human cancer cells, were evaluated. The results showed that at the concentration of 10 mu M (in HBSS buffer) diincarvilones A and B cause a persistent increase in cytoplasmic calcium levels in A549 cells.
关键词Electronic Circular-dichroism Optical-rotation Chemistry Assay
资助信息This work was financially supported by the Open Research Fund of the State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources and grants of the Top Talent Recruitment Program of Yunnan Province (2009C1120 and 20080A007) and 973 Program (2009CB522300).
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np200912p
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000305503500003
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17604
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
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Yan, Yong-Ming,Wu, Gui-Sheng,Dong, Xiao-Ping,et al. Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(6):1025-1029.
APA Yan, Yong-Ming.,Wu, Gui-Sheng.,Dong, Xiao-Ping.,Shen, Lan.,Li, Yan.,...&Cheng, Yong-Xian.(2012).Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation.JOURNAL OF NATURAL PRODUCTS,75(6),1025-1029.
MLA Yan, Yong-Ming,et al."Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation".JOURNAL OF NATURAL PRODUCTS 75.6(2012):1025-1029.
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