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题名: Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation
作者: Yan, Yong-Ming1, 2; Wu, Gui-Sheng1; Dong, Xiao-Ping2; Shen, Lan1; null(李艳)1; Su, Jia1; null(罗怀容)1; Zhu, Hua-Jie1; null(程永现)1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: ELECTRONIC CIRCULAR-DICHROISM ; OPTICAL-ROTATION ; CHEMISTRY ; ASSAY
英文摘要: Diincarvilones A-D (1-4), incarvilone A (5), and a known compound, argutosine B (6), were isolated from Incarvillea arguia. The structures, including the absolute configurations of the new compounds, were determined by NMR spectroscopy, X-ray diffraction analysis, CD spectroscopy, and a variety of computational methods. The biological properties of these substances, including effects on intracellular Ca2+ influx, nitric oxide (NO) production, and human cancer cells, were evaluated. The results showed that at the concentration of 10 mu M (in HBSS buffer) diincarvilones A and B cause a persistent increase in cytoplasmic calcium levels in A549 cells.
出版日期: 2012-06-01
卷号: 75, 期号:6, 页码:1025-1029
DOI标识: 10.1021/np200912p
语种: 英语
ISSN号: 0163-3864
资助信息: This work was financially supported by the Open Research Fund of the State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources and grants of the Top Talent Recruitment Program of Yunnan Province (2009C1120 and 20080A007) and 973 Program (2009CB522300).
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17604
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China

Recommended Citation:
Yan,Yong-Ming;Wu,Gui-Sheng;Dong,Xiao-Ping;Shen,Lan;Li,Yan;Su,Jia;Luo,Huai-Rong;Zhu,Hua-Jie;Cheng,Yong-Xian.Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation,JOURNAL OF NATURAL PRODUCTS,2012,75(6):1025-1029
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