Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation
Yan, Yong-Ming1,2; Wu, Gui-Sheng1; Dong, Xiao-Ping2; Shen, Lan1; Li, Yan1; Su, Jia1; Luo, Huai-Rong1; Zhu, Hua-Jie1; Cheng, Yong-Xian1,2
Corresponding AuthorZhu, HJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China,hjzhu@mail.kib.ac.cn ; yxcheng@mail.kib.ac.cn
2012-06-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume75Issue:6Pages:1025-1029
AbstractDiincarvilones A-D (1-4), incarvilone A (5), and a known compound, argutosine B (6), were isolated from Incarvillea arguia. The structures, including the absolute configurations of the new compounds, were determined by NMR spectroscopy, X-ray diffraction analysis, CD spectroscopy, and a variety of computational methods. The biological properties of these substances, including effects on intracellular Ca2+ influx, nitric oxide (NO) production, and human cancer cells, were evaluated. The results showed that at the concentration of 10 mu M (in HBSS buffer) diincarvilones A and B cause a persistent increase in cytoplasmic calcium levels in A549 cells.
KeywordElectronic Circular-dichroism Optical-rotation Chemistry Assay
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np200912p
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000305503500003
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17604
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
Recommended Citation
GB/T 7714
Yan, Yong-Ming,Wu, Gui-Sheng,Dong, Xiao-Ping,et al. Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(6):1025-1029.
APA Yan, Yong-Ming.,Wu, Gui-Sheng.,Dong, Xiao-Ping.,Shen, Lan.,Li, Yan.,...&Cheng, Yong-Xian.(2012).Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation.JOURNAL OF NATURAL PRODUCTS,75(6),1025-1029.
MLA Yan, Yong-Ming,et al."Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation".JOURNAL OF NATURAL PRODUCTS 75.6(2012):1025-1029.
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