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题名: Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation
作者: Yan, Yong-Ming1, 2; Wu, Gui-Sheng1; Dong, Xiao-Ping2; Shen, Lan1; null(李艳)1; Su, Jia1; null(罗怀容)1; Zhu, Hua-Jie1; null(程永现)1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: ELECTRONIC CIRCULAR-DICHROISM ; OPTICAL-ROTATION ; CHEMISTRY ; ASSAY
英文摘要: Diincarvilones A-D (1-4), incarvilone A (5), and a known compound, argutosine B (6), were isolated from Incarvillea arguia. The structures, including the absolute configurations of the new compounds, were determined by NMR spectroscopy, X-ray diffraction analysis, CD spectroscopy, and a variety of computational methods. The biological properties of these substances, including effects on intracellular Ca2+ influx, nitric oxide (NO) production, and human cancer cells, were evaluated. The results showed that at the concentration of 10 mu M (in HBSS buffer) diincarvilones A and B cause a persistent increase in cytoplasmic calcium levels in A549 cells.
出版日期: 2012-06-01
卷号: 75, 期号:6, 页码:1025-1029
DOI标识: 10.1021/np200912p
语种: 英语
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17604
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China

Recommended Citation:
Yan,Yong-Ming;Wu,Gui-Sheng;Dong,Xiao-Ping;Shen,Lan;Li,Yan;Su,Jia;Luo,Huai-Rong;Zhu,Hua-Jie;Cheng,Yong-Xian.Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation,JOURNAL OF NATURAL PRODUCTS,2012,75(6):1025-1029
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