Chemical Progress in Cyclopeptide-containing Traditional Medicines Cited in Chinese Pharmacopoeia
Zhao Simeng1,2; Kuang Bin1,2; Peng Wenwen1,2; He Wenjun1; Xu Huimin1,2; Ji Changjiu1,2; Han Jing1,2; Zheng Yuqing1,2; Song Weiwu1,2; Tan Ninghu1
2012-06-01
发表期刊CHINESE JOURNAL OF CHEMISTRY
ISSN1001-604X
卷号30期号:6页码:1213-1225
摘要Plant cyclopeptides, cyclic compounds formed mainly by the peptidic bonds of 237 protein and non-protein amino acids (mainly L-amino acids) and found in higher plants, have been attractive for their extensive bioactivities and distinctive molecular architectures. During the last half century's study, about 500 cyclopeptides divided into eight types have been isolated from over 120 species, which belong to over 20 families and 60 genera. Some cyclopeptides showed potential anti-tumor, sedative, immunosuppressive, and uterotonic activities. In the Chinese Pharmacopoeia (CP, 2010 Version), 23 species (14 families, 18 genera) containing cyclopeptides have been recorded in the origins of 24 traditional Chinese medicines (TCMs). Heterophyllin B (64), first reported by us from Pseudostellaria heterophylla in 1993 was cited for the first time in CP as the standard substance of cyclopeptides for quality control. In this review, we highlight the progress in the chemical studies of these cyclopeptide-containing TCMs, in particular recent results in our group's publications.
关键词Cyclopeptide Traditional Chinese Medicine Chemical Constituent
资助信息This work was supported by the National Natural Science Foundation of China (No. U1032602, 91013002, 30725048), the National New Drug Innovation Major Project of China (No. 2011ZX09307-002-02), and the National Basic Research Program of China (No. 2009CB522300).
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17601
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Zhao Simeng,Kuang Bin,Peng Wenwen,et al. Chemical Progress in Cyclopeptide-containing Traditional Medicines Cited in Chinese Pharmacopoeia[J]. CHINESE JOURNAL OF CHEMISTRY,2012,30(6):1213-1225.
APA Zhao Simeng.,Kuang Bin.,Peng Wenwen.,He Wenjun.,Xu Huimin.,...&Tan Ninghu.(2012).Chemical Progress in Cyclopeptide-containing Traditional Medicines Cited in Chinese Pharmacopoeia.CHINESE JOURNAL OF CHEMISTRY,30(6),1213-1225.
MLA Zhao Simeng,et al."Chemical Progress in Cyclopeptide-containing Traditional Medicines Cited in Chinese Pharmacopoeia".CHINESE JOURNAL OF CHEMISTRY 30.6(2012):1213-1225.
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