Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

doi:10.1016/j.fitote.2012.04.007

	Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity
	Zou, Juan 1,2; Jiang, Jing 3; Diao, Yan-Yan 3; Yang, Li-Bin 1; Huang, Jin 3; Li, Hong-Lin 3; Du, Xue 1; Xiao, Wei-Lie 1; Pu, Jian-Xin1 ; Sun, Han-Dong1
通讯作者	Xiao, WL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China,xwl@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
	2012-07-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	83 期号:5 页码:926-931
摘要	Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC50 of 1.50 mu M. (C) 2012 Elsevier B.V. All rights reserved.
关键词	Schisandra Glaucescens Schisandraceae Cycloartane Triterpenoid Fxr Agonistic And antAgonistic Effects
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2012.04.007
收录类别	SCI
语种	英语
WOS记录号	WOS:000305657900018
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/17600
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
推荐引用方式 GB/T 7714	Zou, Juan,Jiang, Jing,Diao, Yan-Yan,et al. Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity[J]. FITOTERAPIA,2012,83(5):926-931.
APA	Zou, Juan.,Jiang, Jing.,Diao, Yan-Yan.,Yang, Li-Bin.,Huang, Jin.,...&Sun, Han-Dong.(2012).Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity.FITOTERAPIA,83(5),926-931.
MLA	Zou, Juan,et al."Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity".FITOTERAPIA 83.5(2012):926-931.

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