Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity
Zou, Juan1,2; Jiang, Jing3; Diao, Yan-Yan3; Yang, Li-Bin1; Huang, Jin3; Li, Hong-Lin3; Du, Xue1; Xiao, Wei-Lie1; Pu, Jian-Xin1; Sun, Han-Dong1
2012-07-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号83期号:5页码:926-931
摘要Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC50 of 1.50 mu M. (C) 2012 Elsevier B.V. All rights reserved.
关键词Schisandra Glaucescens Schisandraceae Cycloartane Triterpenoid Fxr Agonistic And antAgonistic Effects
资助信息This project was supported financially by the NSFC (nos. 20802082 and 30830115), the projects from the Chinese Academy of Sciences (KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China (no. 2009CB522303 and 2009CB940900), the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (awarded to Dr. Hong-Lin Li), and the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q).
学科领域Pharmacology & Pharmacy
DOI10.1016/j.fitote.2012.04.007
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000305657900018
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17600
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
推荐引用方式
GB/T 7714
Zou, Juan,Jiang, Jing,Diao, Yan-Yan,et al. Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity[J]. FITOTERAPIA,2012,83(5):926-931.
APA Zou, Juan.,Jiang, Jing.,Diao, Yan-Yan.,Yang, Li-Bin.,Huang, Jin.,...&Sun, Han-Dong.(2012).Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity.FITOTERAPIA,83(5),926-931.
MLA Zou, Juan,et al."Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity".FITOTERAPIA 83.5(2012):926-931.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Zou-2012-Cycloartane(813KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zou, Juan]的文章
[Jiang, Jing]的文章
[Diao, Yan-Yan]的文章
百度学术
百度学术中相似的文章
[Zou, Juan]的文章
[Jiang, Jing]的文章
[Diao, Yan-Yan]的文章
必应学术
必应学术中相似的文章
[Zou, Juan]的文章
[Jiang, Jing]的文章
[Diao, Yan-Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。