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题名: Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity
作者: Zou, Juan1, 2; Jiang, Jing3; Diao, Yan-Yan3; Yang, Li-Bin1; Huang, Jin3; Li, Hong-Lin3; Du, Xue1; Xiao, Wei-Lie1; Pu, Jian-Xin1; null(孙汉董)1
刊名: FITOTERAPIA
关键词: Schisandra glaucescens ; Schisandraceae ; Cycloartane triterpenoid ; FXR agonistic and antagonistic effects
英文摘要: Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC50 of 1.50 mu M. (C) 2012 Elsevier B.V. All rights reserved.
出版日期: 2012-07-01
卷号: 83, 期号:5, 页码:926-931
DOI标识: 10.1016/j.fitote.2012.04.007
语种: 英语
ISSN号: 0367-326X
资助信息: This project was supported financially by the NSFC (nos. 20802082 and 30830115), the projects from the Chinese Academy of Sciences (KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China (no. 2009CB522303 and 2009CB940900), the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (awarded to Dr. Hong-Lin Li), and the Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q).
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17600
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

Recommended Citation:
Zou,Juan;Jiang,Jing;Diao,Yan-Yan;Yang,Li-Bin;Huang,Jin;Li,Hong-Lin;Du,Xue;Xiao,Wei-Lie;Pu,Jian-Xin;Sun,Han-Dong.Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity,FITOTERAPIA,2012,83(5):926-931
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