Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity
Zou, Juan1,2; Jiang, Jing3; Diao, Yan-Yan3; Yang, Li-Bin1; Huang, Jin3; Li, Hong-Lin3; Du, Xue1; Xiao, Wei-Lie1; Pu, Jian-Xin1; Sun, Han-Dong1
Corresponding AuthorXiao, WL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China,xwl@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn
2012-07-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume83Issue:5Pages:926-931
AbstractFive new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC50 of 1.50 mu M. (C) 2012 Elsevier B.V. All rights reserved.
KeywordSchisandra Glaucescens Schisandraceae Cycloartane Triterpenoid Fxr Agonistic And antAgonistic Effects
Subject AreaPharmacology & Pharmacy
DOI10.1016/j.fitote.2012.04.007
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000305657900018
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17600
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
Recommended Citation
GB/T 7714
Zou, Juan,Jiang, Jing,Diao, Yan-Yan,et al. Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity[J]. FITOTERAPIA,2012,83(5):926-931.
APA Zou, Juan.,Jiang, Jing.,Diao, Yan-Yan.,Yang, Li-Bin.,Huang, Jin.,...&Sun, Han-Dong.(2012).Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity.FITOTERAPIA,83(5),926-931.
MLA Zou, Juan,et al."Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity".FITOTERAPIA 83.5(2012):926-931.
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