Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia

doi:10.1007/s12272-001-2149-3

	Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia
	Tao, Hong-Wen ; Hao, Xiao-Jiang2 ; Liu, Pei-Pei ; Zhu, Wei-Ming 1
	2008-12-01
发表期刊	ARCHIVES OF PHARMACAL RESEARCH
ISSN	0253-6269
卷号	31 期号:12 页码:1547-1551
摘要	A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC(50) values of 2.7 and 9.0 mu M, respectively. The (13)C-NMR data of euphoscopin F (2), epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.
关键词	Diterpenoid Euphornin l X-ray Euphorbia Helioscopia l Cytotoxicity
学科领域	Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI	10.1007/s12272-001-2149-3
收录类别	SCI
语种	英语
WOS记录号	WOS:000261938900005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1753
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Tao, Hong-Wen,Hao, Xiao-Jiang,Liu, Pei-Pei,et al. Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia[J]. ARCHIVES OF PHARMACAL RESEARCH,2008,31(12):1547-1551.
APA	Tao, Hong-Wen,Hao, Xiao-Jiang,Liu, Pei-Pei,&Zhu, Wei-Ming.(2008).Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia.ARCHIVES OF PHARMACAL RESEARCH,31(12),1547-1551.
MLA	Tao, Hong-Wen,et al."Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia".ARCHIVES OF PHARMACAL RESEARCH 31.12(2008):1547-1551.

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