| Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis | |
Dong, Fa-Wu1,2; Fan, Wei-Wei1; Xu, Feng-Qing1; Wan, Qin-Li1; Su, Jia1; Li, Yan1 ; Zhou, Lu1; Zhou, Jun1; Hu, Jiang-Miao1
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| 通讯作者 | Zhou,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; hujiangmiao@mail.kib.ac.cn |
| 2013-12-01 | |
| 发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| ISSN | 1028-6020 |
| 卷号 | 15期号:12页码:1256-1264 |
| 摘要 | Three new stilbenoids, 1-(4-hydroxybenzyl)-imbricatin (1), (E)-4-hydroxy-2,3,3,5-tetramethoxystilbene (2), and (E)-3,4-dihydroxy-2,6-bis(4-hydroxybenzyl)-2,3,5-trimethoxystilbene (3), together with 15 known stilbene derivatives, were isolated from Pholidota yunnanensis. Their structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Furthermore, the inhibitory activities on nitric oxide (NO) production of the isolated compounds were examined in murine macrophages (RAW 264.7) activated by lipopolysaccharide. The cytotoxicity of 18 compounds was determined by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. Among the tested compounds, eight stilbenoids, including three dihydrophenanthrenes, three stilbenes, and one bibenzyl derivative showed inhibitory effects on NO production without cytotoxicity with IC50 values ranging from 4.07 to 7.77M, as compared to MG-132, which was used as a positive control (IC50 of 0.10M). One dihydrophenanthrene, phoyunnanin C (5), showed cytotoxic effects at the test concentrations. |
| 关键词 | Pholidota Yunnanensis Orchidaceae Stilbenoids Raw 264 7 Macrophages Nitric Oxide |
| DOI | 10.1080/10286020.2013.837453 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000328317400006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17454 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Fa-Wu,Fan, Wei-Wei,Xu, Feng-Qing,et al. Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(12):1256-1264. |
| APA | Dong, Fa-Wu.,Fan, Wei-Wei.,Xu, Feng-Qing.,Wan, Qin-Li.,Su, Jia.,...&Hu, Jiang-Miao.(2013).Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(12),1256-1264. |
| MLA | Dong, Fa-Wu,et al."Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.12(2013):1256-1264. |
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