中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis
作者: Dong, Fa-Wu1, 2; Fan, Wei-Wei1; Xu, Feng-Qing1; Wan, Qin-Li1; Su, Jia1; null(李艳)1; Zhou, Lu1; Zhou, Jun1; Hu, Jiang-Miao1
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
关键词: Pholidota yunnanensis ; Orchidaceae ; stilbenoids ; RAW 264 ; 7 macrophages ; nitric oxide
英文摘要: Three new stilbenoids, 1-(4-hydroxybenzyl)-imbricatin (1), (E)-4-hydroxy-2,3,3,5-tetramethoxystilbene (2), and (E)-3,4-dihydroxy-2,6-bis(4-hydroxybenzyl)-2,3,5-trimethoxystilbene (3), together with 15 known stilbene derivatives, were isolated from Pholidota yunnanensis. Their structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Furthermore, the inhibitory activities on nitric oxide (NO) production of the isolated compounds were examined in murine macrophages (RAW 264.7) activated by lipopolysaccharide. The cytotoxicity of 18 compounds was determined by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. Among the tested compounds, eight stilbenoids, including three dihydrophenanthrenes, three stilbenes, and one bibenzyl derivative showed inhibitory effects on NO production without cytotoxicity with IC50 values ranging from 4.07 to 7.77M, as compared to MG-132, which was used as a positive control (IC50 of 0.10M). One dihydrophenanthrene, phoyunnanin C (5), showed cytotoxic effects at the test concentrations.
出版日期: 2013-12-01
卷号: 15, 期号:12, 页码:1256-1264
语种: 英语
收录类别: SCI ; IC
ISSN号: 1028-6020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17454
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
10286020.2013.837453.pdf(164KB)----开放获取View Download

作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Dong,Fa-Wu;Fan,Wei-Wei;Xu,Feng-Qing;Wan,Qin-Li;Su,Jia;Li,Yan;Zhou,Lu;Zhou,Jun;Hu,Jiang-Miao.Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis,JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(12):1256-1264
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Dong, Fa-Wu]'s Articles
[Fan, Wei-Wei]'s Articles
[Xu, Feng-Qing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Dong, Fa-Wu]‘s Articles
[Fan, Wei-Wei]‘s Articles
[Xu, Feng-Qing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 10286020.2013.837453.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace