Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis
Dong, Fa-Wu1,2; Fan, Wei-Wei1; Xu, Feng-Qing1; Wan, Qin-Li1; Su, Jia1; Li, Yan1; Zhou, Lu1; Zhou, Jun1; Hu, Jiang-Miao1
Corresponding AuthorZhou,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; hujiangmiao@mail.kib.ac.cn
2013-12-01
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
Volume15Issue:12Pages:1256-1264
AbstractThree new stilbenoids, 1-(4-hydroxybenzyl)-imbricatin (1), (E)-4-hydroxy-2,3,3,5-tetramethoxystilbene (2), and (E)-3,4-dihydroxy-2,6-bis(4-hydroxybenzyl)-2,3,5-trimethoxystilbene (3), together with 15 known stilbene derivatives, were isolated from Pholidota yunnanensis. Their structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Furthermore, the inhibitory activities on nitric oxide (NO) production of the isolated compounds were examined in murine macrophages (RAW 264.7) activated by lipopolysaccharide. The cytotoxicity of 18 compounds was determined by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. Among the tested compounds, eight stilbenoids, including three dihydrophenanthrenes, three stilbenes, and one bibenzyl derivative showed inhibitory effects on NO production without cytotoxicity with IC50 values ranging from 4.07 to 7.77M, as compared to MG-132, which was used as a positive control (IC50 of 0.10M). One dihydrophenanthrene, phoyunnanin C (5), showed cytotoxic effects at the test concentrations.
KeywordPholidota Yunnanensis Orchidaceae Stilbenoids Raw 264 7 Macrophages Nitric Oxide
DOI10.1080/10286020.2013.837453
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000328317400006
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17454
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Dong, Fa-Wu,Fan, Wei-Wei,Xu, Feng-Qing,et al. Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(12):1256-1264.
APA Dong, Fa-Wu.,Fan, Wei-Wei.,Xu, Feng-Qing.,Wan, Qin-Li.,Su, Jia.,...&Hu, Jiang-Miao.(2013).Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(12),1256-1264.
MLA Dong, Fa-Wu,et al."Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.12(2013):1256-1264.
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