Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis
Dong, Fa-Wu1,2; Fan, Wei-Wei1; Xu, Feng-Qing1; Wan, Qin-Li1; Su, Jia1; Li, Yan1; Zhou, Lu1; Zhou, Jun1; Hu, Jiang-Miao1
2013-12-01
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
卷号15期号:12页码:1256-1264
摘要Three new stilbenoids, 1-(4-hydroxybenzyl)-imbricatin (1), (E)-4-hydroxy-2,3,3,5-tetramethoxystilbene (2), and (E)-3,4-dihydroxy-2,6-bis(4-hydroxybenzyl)-2,3,5-trimethoxystilbene (3), together with 15 known stilbene derivatives, were isolated from Pholidota yunnanensis. Their structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Furthermore, the inhibitory activities on nitric oxide (NO) production of the isolated compounds were examined in murine macrophages (RAW 264.7) activated by lipopolysaccharide. The cytotoxicity of 18 compounds was determined by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. Among the tested compounds, eight stilbenoids, including three dihydrophenanthrenes, three stilbenes, and one bibenzyl derivative showed inhibitory effects on NO production without cytotoxicity with IC50 values ranging from 4.07 to 7.77M, as compared to MG-132, which was used as a positive control (IC50 of 0.10M). One dihydrophenanthrene, phoyunnanin C (5), showed cytotoxic effects at the test concentrations.
关键词Pholidota Yunnanensis Orchidaceae Stilbenoids Raw 264 7 Macrophages Nitric Oxide
DOI10.1080/10286020.2013.837453
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000328317400006
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17454
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Dong, Fa-Wu,Fan, Wei-Wei,Xu, Feng-Qing,et al. Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2013,15(12):1256-1264.
APA Dong, Fa-Wu.,Fan, Wei-Wei.,Xu, Feng-Qing.,Wan, Qin-Li.,Su, Jia.,...&Hu, Jiang-Miao.(2013).Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,15(12),1256-1264.
MLA Dong, Fa-Wu,et al."Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 15.12(2013):1256-1264.
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