Acylated iridoid glycosides and acylated rhamnopyranoses from Gmelina arborea flowers
Gu, Wei1,2; Hao, Xiao-Jiang3; Liu, Hong-Xin1,2; Wang, Yue-Hu1; Long, Chun-Lin1,4
2013-11-01
发表期刊PHYTOCHEMISTRY LETTERS
ISSN1874-3900
卷号6期号:4页码:681-685
摘要Nine acylated iridoid glycosides (1-9), five acylated rhamnopyranoses (10-14) and verbascoside (15) were isolated from Gmelina arborea flowers, including 5 new compounds (1, 2, and 10-12). The cytoprotective activity of 11 selected compounds (1-8, 10, 11, and 15) against CCl4-induced cytotoxicity on liver was determined. Compounds 1, 2, 4, 7, 8 and 15 displayed hepatoprotective activity. 6-O-alpha-L-(2 '',3 ''-di-O-trans-p-hydroxycinnamoyl)rhamnopyranosylcatalpol (2) exhibited the most potent cytoprotective effect with an EC50 value of 42.5 mu M (SI = 19.3) compared with biphenyldimethylesterate (DDB, EC50 = 277.3 mu M, SI = 9.8) and bicylo-ethanol (EC50 = 279.2 mu M, SI = 12.2). Among the acylated iridoid glycosides, the compounds (2 and 8) containing phenolic hydroxy groups were more active than were those lacking them. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词Gmelina Arborea Iridoid Glycosides Acylated Rhamnopyranoses Phenylethanoid Cytoprotective Activity
学科领域Biochemistry & Molecular Biology ; Plant Sciences
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000325872700038
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17435
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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GB/T 7714
Gu, Wei,Hao, Xiao-Jiang,Liu, Hong-Xin,et al. Acylated iridoid glycosides and acylated rhamnopyranoses from Gmelina arborea flowers[J]. PHYTOCHEMISTRY LETTERS,2013,6(4):681-685.
APA Gu, Wei,Hao, Xiao-Jiang,Liu, Hong-Xin,Wang, Yue-Hu,&Long, Chun-Lin.(2013).Acylated iridoid glycosides and acylated rhamnopyranoses from Gmelina arborea flowers.PHYTOCHEMISTRY LETTERS,6(4),681-685.
MLA Gu, Wei,et al."Acylated iridoid glycosides and acylated rhamnopyranoses from Gmelina arborea flowers".PHYTOCHEMISTRY LETTERS 6.4(2013):681-685.
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