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题名: Acylated iridoid glycosides and acylated rhamnopyranoses from Gmelina arborea flowers
作者: Gu, Wei1, 2; null(郝小江)3; Liu, Hong-Xin1, 2; Wang YueHu(王跃虎)1; Long, Chun-Lin1, 4
刊名: PHYTOCHEMISTRY LETTERS
关键词: Gmelina arborea ; Iridoid glycosides ; Acylated rhamnopyranoses ; Phenylethanoid ; Cytoprotective activity
英文摘要: Nine acylated iridoid glycosides (1-9), five acylated rhamnopyranoses (10-14) and verbascoside (15) were isolated from Gmelina arborea flowers, including 5 new compounds (1, 2, and 10-12). The cytoprotective activity of 11 selected compounds (1-8, 10, 11, and 15) against CCl4-induced cytotoxicity on liver was determined. Compounds 1, 2, 4, 7, 8 and 15 displayed hepatoprotective activity. 6-O-alpha-L-(2 '',3 ''-di-O-trans-p-hydroxycinnamoyl)rhamnopyranosylcatalpol (2) exhibited the most potent cytoprotective effect with an EC50 value of 42.5 mu M (SI = 19.3) compared with biphenyldimethylesterate (DDB, EC50 = 277.3 mu M, SI = 9.8) and bicylo-ethanol (EC50 = 279.2 mu M, SI = 12.2). Among the acylated iridoid glycosides, the compounds (2 and 8) containing phenolic hydroxy groups were more active than were those lacking them. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
出版日期: 2013-11-01
卷号: 6, 期号:4, 页码:681-685
语种: 英语
ISSN号: 1874-3900
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17435
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
4.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China

Recommended Citation:
Gu,Wei;Hao,Xiao-Jiang;Liu,Hong-Xin;Wang,Yue-Hu;Long,Chun-Lin.Acylated iridoid glycosides and acylated rhamnopyranoses from Gmelina arborea flowers,PHYTOCHEMISTRY LETTERS,2013,6(4):681-685
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