| Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense | |
Zhao, Da-Ke1; Ai, Hong-Lian2; Zi, Shu-Hui2; Zhang, Li-Mei2; Yang, Sheng-Chao2; Guo, Hua-Chun2; Shen, Yong2; Chen, Yan-Ping2; Chen, Ji-Jun3
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| 通讯作者 | Shen,Y (reprint author),Yunnan Agr Univ,Coll Agr & Biotechnol,Kunming 650201,Peoples R China.,pharmsy@sina.com ; chenjj@mail.kib.ac.cn |
| 2013-12-01 | |
| 发表期刊 | FITOTERAPIA
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| ISSN | 0367-326X |
| 卷号 | 91页码:280-283 |
| 摘要 | Four new C-18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg. (C) 2013 Elsevier B.V. All rights reserved. |
| 关键词 | Diterpenoid Alkaloids Weisaconitines A-d Analgesic Activity Aconitum Weixiense Ranunculaceae |
| 学科领域 | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327574300040 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17419 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Agr, Kunming 650091, Peoples R China 2.Yunnan Agr Univ, Coll Agr & Biotechnol, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Da-Ke,Ai, Hong-Lian,Zi, Shu-Hui,et al. Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense[J]. FITOTERAPIA,2013,91:280-283. |
| APA | Zhao, Da-Ke.,Ai, Hong-Lian.,Zi, Shu-Hui.,Zhang, Li-Mei.,Yang, Sheng-Chao.,...&Chen, Ji-Jun.(2013).Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense.FITOTERAPIA,91,280-283. |
| MLA | Zhao, Da-Ke,et al."Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense".FITOTERAPIA 91(2013):280-283. |
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