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题名: Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense
作者: Zhao, Da-Ke1; Ai, Hong-Lian2; Zi, Shu-Hui2; Zhang, Li-Mei2; Yang, Sheng-Chao2; Guo, Hua-Chun2; Shen, Yong2; Chen, Yan-Ping2; null(陈纪军)3
刊名: FITOTERAPIA
关键词: Diterpenoid alkaloids ; Weisaconitines A-D ; Analgesic activity ; Aconitum weixiense ; Ranunculaceae
英文摘要: Four new C-18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg. (C) 2013 Elsevier B.V. All rights reserved.
出版日期: 2013-12-01
卷号: 91, 页码:280-283
语种: 英语
ISSN号: 0367-326X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17419
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ, Sch Agr, Kunming 650091, Peoples R China
2.Yunnan Agr Univ, Coll Agr & Biotechnol, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

Recommended Citation:
Zhao,Da-Ke;Ai,Hong-Lian;Zi,Shu-Hui;Zhang,Li-Mei;Yang,Sheng-Chao;Guo,Hua-Chun;Shen,Yong;Chen,Yan-Ping;Chen,Ji-Jun.Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense,FITOTERAPIA,2013,91():280-283
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