Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense
Zhao, Da-Ke1; Ai, Hong-Lian2; Zi, Shu-Hui2; Zhang, Li-Mei2; Yang, Sheng-Chao2; Guo, Hua-Chun2; Shen, Yong2; Chen, Yan-Ping2; Chen, Ji-Jun3
2013-12-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号91页码:280-283
摘要Four new C-18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg. (C) 2013 Elsevier B.V. All rights reserved.
关键词Diterpenoid Alkaloids Weisaconitines A-d Analgesic Activity Aconitum Weixiense Ranunculaceae
资助信息State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS [P2012-KF04];National Natural Science Foundation of China [21362045];project of Sciences and Technology Department of Yunnan Province [2012CG007]
学科领域Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000327574300040
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17419
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Sch Agr, Kunming 650091, Peoples R China
2.Yunnan Agr Univ, Coll Agr & Biotechnol, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Zhao, Da-Ke,Ai, Hong-Lian,Zi, Shu-Hui,et al. Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense[J]. FITOTERAPIA,2013,91:280-283.
APA Zhao, Da-Ke.,Ai, Hong-Lian.,Zi, Shu-Hui.,Zhang, Li-Mei.,Yang, Sheng-Chao.,...&Chen, Ji-Jun.(2013).Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense.FITOTERAPIA,91,280-283.
MLA Zhao, Da-Ke,et al."Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense".FITOTERAPIA 91(2013):280-283.
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