Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum
Yan, Yong-Ming1,3; Ai, Jun2; Zhou, Li-Li2; Chung, Arthur C. K.4; Li, Rong4; Nie, Jing2; Fang, Ping1; Wang, Xin-Long1; Luo, Jie1; Hu, Qun1; Hou, Fan-Fan2; Cheng, Yong-Xian1
2013-11-01
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号15期号:21页码:5488-5491
摘要(+)-Lingzhiol and (-)-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures were identified by spectroscopic methods and X-ray diffraction crystallography. Lingzhiol bears an unusual 5/5/6/6 ring system characteristic of sharing a C-3'-C-7' axis. Biological evaluation showed that (+)-lingzhiol or ()-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-beta 1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions.
关键词Diabetic-nephropathy High-glucose Mesangial Cells Up-regulation Expression Activation Pathways
资助信息NSFC-Joint Foundation of Yunnan Province [U1202222];State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P2013-ZZ03];Research Grant Council of Hong Kong [GRF 463612]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17415
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Educ Minist, Div Nephrol,Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
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Yan, Yong-Ming,Ai, Jun,Zhou, Li-Li,et al. Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum[J]. ORGANIC LETTERS,2013,15(21):5488-5491.
APA Yan, Yong-Ming.,Ai, Jun.,Zhou, Li-Li.,Chung, Arthur C. K..,Li, Rong.,...&Cheng, Yong-Xian.(2013).Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum.ORGANIC LETTERS,15(21),5488-5491.
MLA Yan, Yong-Ming,et al."Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum".ORGANIC LETTERS 15.21(2013):5488-5491.
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