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题名: Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum
作者: Yan, Yong-Ming1, 3; Ai, Jun2; Zhou, Li-Li2; Chung, Arthur C. K.4; Li, Rong4; Nie, Jing2; Fang, Ping1; Wang, Xin-Long1; Luo, Jie1; Hu, Qun1; Hou, Fan-Fan2; null(程永现)1
刊名: ORGANIC LETTERS
关键词: DIABETIC-NEPHROPATHY ; HIGH-GLUCOSE ; MESANGIAL CELLS ; UP-REGULATION ; EXPRESSION ; ACTIVATION ; PATHWAYS
英文摘要: (+)-Lingzhiol and (-)-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures were identified by spectroscopic methods and X-ray diffraction crystallography. Lingzhiol bears an unusual 5/5/6/6 ring system characteristic of sharing a C-3'-C-7' axis. Biological evaluation showed that (+)-lingzhiol or ()-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-beta 1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions.
出版日期: 2013-11-01
卷号: 15, 期号:21, 页码:5488-5491
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry
ISSN号: 1523-7060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17415
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Educ Minist, Div Nephrol,Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

Recommended Citation:
Yan,Yong-Ming;Ai,Jun;Zhou,Li-Li;Chung,Arthur C. K.;Li,Rong;Nie,Jing;Fang,Ping;Wang,Xin-Long;Luo,Jie;Hu,Qun;Hou,Fan-Fan;Cheng,Yong-Xian.Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum,ORGANIC LETTERS,2013,15(21):5488-5491
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