A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata | |
Peng, Wen-Wen1,2; Zeng, Guang-Zhi1; Song, Wei-Wu1,2; Tan, Ning-Hua1 | |
通讯作者 | Zeng,GZ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.,gzh_zeng@mail.kib.ac.cn ; nhtan@mail.kib.ac.cn |
2013-07-01 | |
发表期刊 | CHEMISTRY & BIODIVERSITY |
ISSN | 1612-1872 |
卷号 | 10期号:7页码:1317-1321 |
摘要 | One new carbazole alkaloid, excavatine A (1), and two additional new alkaloids, excavatine B (2) and excavatine C (3), were isolated from the stems and leaves of Clausena excavataBurm.f. (Rutaceae). Their structures were determined on the basis of detailed spectroscopic analyses, especially 2D-NMR and HR-EI-MS data. Compounds 1-3 were tested for their cytotoxic activities against A549, HeLa, and BGC-823 cancer cell lines, and for their antimicrobial activities against Candida albicans and Staphylococcus aureus. Only 1 exhibited cytotoxicity against A549 and HeLa cell lines with the IC50 values of 5.25 and 1.91g/ml, respectively. |
关键词 | Clausena Excavata Carbazole Alkaloids Alkaloids Excavatines A-c Cytotoxic Activity |
学科领域 | Biochemistry & Molecular Biology ; Chemistry |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000327697400014 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/17406 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Peng, Wen-Wen,Zeng, Guang-Zhi,Song, Wei-Wu,et al. A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata[J]. CHEMISTRY & BIODIVERSITY,2013,10(7):1317-1321. |
APA | Peng, Wen-Wen,Zeng, Guang-Zhi,Song, Wei-Wu,&Tan, Ning-Hua.(2013).A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata.CHEMISTRY & BIODIVERSITY,10(7),1317-1321. |
MLA | Peng, Wen-Wen,et al."A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata".CHEMISTRY & BIODIVERSITY 10.7(2013):1317-1321. |
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