A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata
Peng, Wen-Wen1,2; Zeng, Guang-Zhi1; Song, Wei-Wu1,2; Tan, Ning-Hua1
2013-07-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号10期号:7页码:1317-1321
摘要One new carbazole alkaloid, excavatine A (1), and two additional new alkaloids, excavatine B (2) and excavatine C (3), were isolated from the stems and leaves of Clausena excavataBurm.f. (Rutaceae). Their structures were determined on the basis of detailed spectroscopic analyses, especially 2D-NMR and HR-EI-MS data. Compounds 1-3 were tested for their cytotoxic activities against A549, HeLa, and BGC-823 cancer cell lines, and for their antimicrobial activities against Candida albicans and Staphylococcus aureus. Only 1 exhibited cytotoxicity against A549 and HeLa cell lines with the IC50 values of 5.25 and 1.91g/ml, respectively.
关键词Clausena Excavata Carbazole Alkaloids Alkaloids Excavatines A-c Cytotoxic Activity
资助信息National New Drug Innovation Major Project of China [2011ZX09307-002-02];National Natural Science Foundation of China [U1032602, 91013002, 30725048, 201102152];National Basic Research Program of China [2009CB522300, 2013CB127505];Chinese Academy of Sciences;Natural Science Foundation of Yunnan Province [2012GA003]
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17406
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Peng, Wen-Wen,Zeng, Guang-Zhi,Song, Wei-Wu,et al. A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata[J]. CHEMISTRY & BIODIVERSITY,2013,10(7):1317-1321.
APA Peng, Wen-Wen,Zeng, Guang-Zhi,Song, Wei-Wu,&Tan, Ning-Hua.(2013).A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata.CHEMISTRY & BIODIVERSITY,10(7),1317-1321.
MLA Peng, Wen-Wen,et al."A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata".CHEMISTRY & BIODIVERSITY 10.7(2013):1317-1321.
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