Phytochemical and genetic analyses of ancient cannabis from Central Asia
Russo, Ethan B.1,2; Jiang, Hong-En3,4; Li, Xiao4; Sutton, Alan1; Carboni, Andrea5; del Bianco, Francesca5; Mandolino, Giuseppe5; Potter, David J.1; Zhao, You-Xing6; Bera, Subir7; Zhang, Yong-Bing4; Lue, En-Guo8; Ferguson, David K.9; Hueber, Francis10; Zhao, Liang-Cheng11; Liu, Chang-Jiang3; Wang, Yu-Fei3; Li, Cheng-Sen4,12
2008-11-01
Source PublicationJOURNAL OF EXPERIMENTAL BOTANY
ISSN0022-0957
Volume59Issue:15Pages:4171-4182
AbstractThe Yanghai Tombs near Turpan, Xinjiang-Uighur Autonomous Region, China have recently been excavated to reveal the 2700-year-old grave of a Caucasoid shaman whose accoutrements included a large cache of cannabis, superbly preserved by climatic and burial conditions. A multidisciplinary international team demonstrated through botanical examination, phytochemical investigation, and genetic deoxyribonucleic acid analysis by polymerase chain reaction that this material contained tetrahydrocannabinol, the psychoactive component of cannabis, its oxidative degradation product, cannabinol, other metabolites, and its synthetic enzyme, tetrahydrocannabinolic acid synthase, as well as a novel genetic variant with two single nucleotide polymorphisms. The cannabis was presumably employed by this culture as a medicinal or psychoactive agent, or an aid to divination. To our knowledge, these investigations provide the oldest documentation of cannabis as a pharmacologically active agent, and contribute to the medical and archaeological record of this pre-Silk Road culture.
KeywordYanghai Tombs Sativa l China Dna Amplification Cannabaceae Xinjiang
Subject AreaPlant Sciences
DOI10.1093/jxb/ern260
Indexed BySCI ; AHCI
Language英语
WOS Research AreaPlant Sciences
WOS SubjectPlant Sciences
WOS IDWOS:000261280000010
Citation statistics
Cited Times:80[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1735
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.GW Pharmaceut, Salisbury SP4 0JQ, Wilts, England
2.Univ Montana, Fac Affiliate, Dept Pharmaceut Sci, Missoula, MT 59812 USA
3.Chinese Acad Sci, Inst Bot, Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China
4.Bur Cultural Rel Turpan Prefecture, Turpan 838000, Xinjiang, Peoples R China
5.CRA Ctr Recerca Colture Ind, I-40128 Bologna, Italy
6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
7.Univ Calcutta, Dept Bot, Kolkata 700019, W Bengal, India
8.Xinjiang Inst Archaeol, Urumqi 830011, Xinjiang, Peoples R China
9.Univ Vienna, Inst Palaeontol, A-1090 Vienna, Austria
10.Smithsonian Inst, Dept Paleobiol, Washington, DC 20560 USA
11.Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Beijing 100083, Peoples R China
12.Beijing Museum Nat Hist, Beijing 100050, Peoples R China
Recommended Citation
GB/T 7714
Russo, Ethan B.,Jiang, Hong-En,Li, Xiao,et al. Phytochemical and genetic analyses of ancient cannabis from Central Asia[J]. JOURNAL OF EXPERIMENTAL BOTANY,2008,59(15):4171-4182.
APA Russo, Ethan B..,Jiang, Hong-En.,Li, Xiao.,Sutton, Alan.,Carboni, Andrea.,...&Li, Cheng-Sen.(2008).Phytochemical and genetic analyses of ancient cannabis from Central Asia.JOURNAL OF EXPERIMENTAL BOTANY,59(15),4171-4182.
MLA Russo, Ethan B.,et al."Phytochemical and genetic analyses of ancient cannabis from Central Asia".JOURNAL OF EXPERIMENTAL BOTANY 59.15(2008):4171-4182.
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