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题名: Phytochemical and genetic analyses of ancient cannabis from Central Asia
作者: Russo, Ethan B.1, 2; Jiang, Hong-En3, 4; Li, Xiao4; Sutton, Alan1; Carboni, Andrea5; del Bianco, Francesca5; Mandolino, Giuseppe5; Potter, David J.1; Zhao, You-Xing6; Bera, Subir7; Zhang, Yong-Bing4; Lue, En-Guo8; Ferguson, David K.9; Hueber, Francis10; Zhao, Liang-Cheng11; Liu, Chang-Jiang3; Wang, Yu-Fei3; Li, Cheng-Sen4, 12
刊名: JOURNAL OF EXPERIMENTAL BOTANY
关键词: YANGHAI TOMBS ; SATIVA L ; CHINA ; DNA ; AMPLIFICATION ; CANNABACEAE ; XINJIANG
英文摘要: The Yanghai Tombs near Turpan, Xinjiang-Uighur Autonomous Region, China have recently been excavated to reveal the 2700-year-old grave of a Caucasoid shaman whose accoutrements included a large cache of cannabis, superbly preserved by climatic and burial conditions. A multidisciplinary international team demonstrated through botanical examination, phytochemical investigation, and genetic deoxyribonucleic acid analysis by polymerase chain reaction that this material contained tetrahydrocannabinol, the psychoactive component of cannabis, its oxidative degradation product, cannabinol, other metabolites, and its synthetic enzyme, tetrahydrocannabinolic acid synthase, as well as a novel genetic variant with two single nucleotide polymorphisms. The cannabis was presumably employed by this culture as a medicinal or psychoactive agent, or an aid to divination. To our knowledge, these investigations provide the oldest documentation of cannabis as a pharmacologically active agent, and contribute to the medical and archaeological record of this pre-Silk Road culture.
出版日期: 2008-11-01
卷号: 59, 期号:15, 页码:4171-4182
语种: 英语
收录类别: SCI ; AHCI
学科分类: Plant Sciences
ISSN号: 0022-0957
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1735
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.GW Pharmaceut, Salisbury SP4 0JQ, Wilts, England
2.Univ Montana, Fac Affiliate, Dept Pharmaceut Sci, Missoula, MT 59812 USA
3.Chinese Acad Sci, Inst Bot, Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China
4.Bur Cultural Rel Turpan Prefecture, Turpan 838000, Xinjiang, Peoples R China
5.CRA Ctr Recerca Colture Ind, I-40128 Bologna, Italy
6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
7.Univ Calcutta, Dept Bot, Kolkata 700019, W Bengal, India
8.Xinjiang Inst Archaeol, Urumqi 830011, Xinjiang, Peoples R China
9.Univ Vienna, Inst Palaeontol, A-1090 Vienna, Austria
10.Smithsonian Inst, Dept Paleobiol, Washington, DC 20560 USA
11.Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Beijing 100083, Peoples R China
12.Beijing Museum Nat Hist, Beijing 100050, Peoples R China

Recommended Citation:
Russo, EB; Jiang, HE; Li, X; Sutton, A; Carboni, A; del Bianco, F; Mandolino, G; Potter, DJ; Zhao, YX; Bera, S; Zhang, YB; Lu, EG; Ferguson, DK; Hueber, F; Zhao, LC; Liu, CJ; Wang, YF; Li, CS.Phytochemical and genetic analyses of ancient cannabis from Central Asia,JOURNAL OF EXPERIMENTAL BOTANY,2008,59(15):4171-4182
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