Diterpenoid compounds from Vitex agnus-castus
Pal, Mahesh1,2; Li, Sheng-Hong2; Tewari, Shri Krishan1; Sun, Han-Dong2
2013-09-01
发表期刊CHEMISTRY OF NATURAL COMPOUNDS
ISSN0009-3130
卷号49期号:4页码:635-638
摘要A new diterpenoid alkaloid having an alpha,beta-unsaturated gamma-lactam moiety, 9 alpha-hydroxy-13(14)-labden-16,15-amide (1), together with five known ones, was isolated from the fruits of Vitex angus-castus. The structure of 1 was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques.The cytotoxicity of each compound was evaluated against human chronic myelogenous leukemia (K562) cell lines. Compound 1 was found to be the most potent with IC50 value of 0.70 mu g/mL.
关键词Diterpenoid Vitex Agnus-castus Verbenaceae Vitexlactam Cytotoxicity
学科领域Chemistry, Medicinal ; Chemistry, Organic
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000324830200012
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17284
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Natl Bot Res Inst, CSIR, Phytochem Div, Lucknow 226001, Uttar Pradesh, India
2.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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Pal, Mahesh,Li, Sheng-Hong,Tewari, Shri Krishan,et al. Diterpenoid compounds from Vitex agnus-castus[J]. CHEMISTRY OF NATURAL COMPOUNDS,2013,49(4):635-638.
APA Pal, Mahesh,Li, Sheng-Hong,Tewari, Shri Krishan,&Sun, Han-Dong.(2013).Diterpenoid compounds from Vitex agnus-castus.CHEMISTRY OF NATURAL COMPOUNDS,49(4),635-638.
MLA Pal, Mahesh,et al."Diterpenoid compounds from Vitex agnus-castus".CHEMISTRY OF NATURAL COMPOUNDS 49.4(2013):635-638.
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