Diterpenoid compounds from Vitex agnus-castus
Pal, Mahesh1,2; Li, Sheng-Hong2; Tewari, Shri Krishan1; Sun, Han-Dong2
Corresponding AuthorPal, M (reprint author), Natl Bot Res Inst, CSIR, Phytochem Div, Lucknow 226001, Uttar Pradesh, India.,drmpal.nbri@rediffmail.com
AbstractA new diterpenoid alkaloid having an alpha,beta-unsaturated gamma-lactam moiety, 9 alpha-hydroxy-13(14)-labden-16,15-amide (1), together with five known ones, was isolated from the fruits of Vitex angus-castus. The structure of 1 was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques.The cytotoxicity of each compound was evaluated against human chronic myelogenous leukemia (K562) cell lines. Compound 1 was found to be the most potent with IC50 value of 0.70 mu g/mL.
KeywordDiterpenoid Vitex Agnus-castus Verbenaceae Vitexlactam Cytotoxicity
Subject AreaChemistry, Medicinal ; Chemistry, Organic
Indexed BySCI ; IC
WOS IDWOS:000324830200012
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Document Type期刊论文
Affiliation1.Natl Bot Res Inst, CSIR, Phytochem Div, Lucknow 226001, Uttar Pradesh, India
2.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Pal, Mahesh,Li, Sheng-Hong,Tewari, Shri Krishan,et al. Diterpenoid compounds from Vitex agnus-castus[J]. CHEMISTRY OF NATURAL COMPOUNDS,2013,49(4):635-638.
APA Pal, Mahesh,Li, Sheng-Hong,Tewari, Shri Krishan,&Sun, Han-Dong.(2013).Diterpenoid compounds from Vitex agnus-castus.CHEMISTRY OF NATURAL COMPOUNDS,49(4),635-638.
MLA Pal, Mahesh,et al."Diterpenoid compounds from Vitex agnus-castus".CHEMISTRY OF NATURAL COMPOUNDS 49.4(2013):635-638.
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