中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway
作者: Deng, Q.1, 2, 3; Yu, X.1, 2, 3; Xiao, L.1, 2, 3; Hu, Z.1, 2, 3; null(罗晓东)1, 2, 3; Tao, Y.1, 2, 3; Yang, L.1, 2, 3, 4; Liu, X.1, 2, 3; Chen, H.6; Ding, Z.5; Feng, T.5; Tang, Y.1, 2, 3; Weng, X.1, 2, 3; Gao, J.1, 2, 3; Yi, W.1, 2, 3; Bode, A. M.6; Dong, Z.6; Liu, J.5; Cao, Y.1, 2, 3, 4
刊名: CELL DEATH & DISEASE
关键词: neoalbaconol ; PDK1 ; PI3-K/Akt ; energy depletion ; cancer cell death
英文摘要: Many natural compounds derived from plants or microbes show promising potential for anticancer treatment, but few have been found to target energy-relevant regulators. In this study, we report that neoalbaconol (NA), a novel small-molecular compound isolated from the fungus, Albatrellus confluens, could target 3-phosphoinositide-dependent protein kinase 1 (PDK1) and inhibit its downstream phosphoinositide-3 kinase (PI3-K)/Akt-hexokinase 2 (HK2) pathway, which eventually resulted in energy depletion. By targeting PDK1, NA reduced the consumption of glucose and ATP generation, activated autophagy and caused apoptotic and necroptotic death of cancer cells through independent pathway. Necroptosis was remarkably induced, which was confirmed by several necroptosis-specific markers: the activation of autophagy, presence of necrotic morphology, increase of receptor-interacting protein 1 (RIP1)/RIP3 colocalization and interaction and rescued by necroptosis inhibitor necrostatin-1. The possibility that Akt overexpression reversed the NA-induced energy crisis confirmed the importance of the PDK1-Akt-energy pathway in NA-mediated cell death. Moreover, NA shows the capability to inhibit PI3-K/Akt signaling and suppress tumor growth in the nasopharyngeal carcinoma (NPC) nude mouse model. These results supported the feasibility of NA in anticancer treatments.
出版日期: 2013-09-01
卷号: 4, 页码:e804
语种: 英语
收录类别: SCI
学科分类: Cell Biology
ISSN号: 2041-4889
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17282
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Deng-2013-Neoalbaconol induces.pdf(1755KB)----开放获取View Download

作者单位: 1.Cent S Univ, Canc Res Inst, Xiangya Sch Med, Changsha, Hunan, Peoples R China
2.Cent S Univ, Chinese Minist Educ, Key Lab, Changsha, Hunan, Peoples R China
3.Cent S Univ, Chinese Minist Publ Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China
4.Cent S Univ, Mol Imaging Ctr, Changsha, Hunan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
6.Univ Minnesota, Hormel Inst, Austin, MN 55912 USA

Recommended Citation:
Deng, Q.;Yu, X.;Xiao, L.;Hu, Z.;Luo, X.;Tao, Y.;Yang, L.;Liu, X.;Chen, H.;Ding, Z.;Feng, T.;Tang, Y.;Weng, X.;Gao, J.;Yi, W.;Bode, A. M.;Dong, Z.;Liu, J.;Cao, Y..Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway,CELL DEATH & DISEASE,2013,4():e804
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Deng, Q.]'s Articles
[Yu, X.]'s Articles
[Xiao, L.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Deng, Q.]‘s Articles
[Yu, X.]‘s Articles
[Xiao, L.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Deng-2013-Neoalbaconol induces.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace