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题名: Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression
作者: Liu, Qiuyan1, 2; Shu, Xiaoli3; Wang, Li3; Sun, Anna; Liu, Jikai4; Cao, Xuetao1, 2, 3
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
关键词: immunosuppressant ; macrophage ; proinflammatory cytokine ; NF-kappa B ; SOCS1
英文摘要: Discovery and functional identification of plant-derived small compounds as the immunosuppressant attract much attention these years. Albaconol is a new kind of small compound, prenylated resorcinol, isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens. Our previous studies showed that albaconol can inhibit tumor cell growth and dendritic cell maturation. However, the immunomodulatory roles and the underlying mechanisms of albaconol have not been fully understood. In this study we investigated the effects of albaconol on the proliferation and LPS-induced proinflammatory cytokine production of macrophages. Albaconol, when used at a dose higher than 1.0 mu g/ml, inhibited proliferation of RAW264.7 cells in a dose- and time-dependent manner, and could induce cellular apoptosis when used at high dosage (>= 7.5 mu g/ml). Furthermore, we found that albaconol used at a lower dosage without apoptosis induction could significantly inhibit LPS-induced TNF-alpha, IL-6, IL-1 beta and NO production in RAW264.7 cells. The inhibition of NF-kappa B activation and enhancement of SOCS1 expression in LPS-stimulated macrophages by albaconol may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Our results suggest that albaconol may be a potential immunosuppressive and anti-inflammatory drug.
出版日期: 2008-08-01
卷号: 5, 期号:4, 页码:271-278
语种: 英语
收录类别: SCI
学科分类: Immunology
ISSN号: 1672-7681
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1709
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China
2.Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China
3.Zhejiang Univ, Inst Immunol, Hangzhou 310031, Zhejiang, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resourses W China, Kunming 650204, Peoples R China

Recommended Citation:
Liu, QY; Shu, XL; Wang, L; Sun, AN; Liu, JK; Cao, XT.Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression,CELLULAR & MOLECULAR IMMUNOLOGY,2008,5(4):271-278
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