Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression
Liu, Qiuyan1,2; Shu, Xiaoli3; Wang, Li3; Sun, Anna; Liu, Jikai4; Cao, Xuetao1,2,3
2008-08-01
发表期刊CELLULAR & MOLECULAR IMMUNOLOGY
ISSN1672-7681
卷号5期号:4页码:271-278
摘要Discovery and functional identification of plant-derived small compounds as the immunosuppressant attract much attention these years. Albaconol is a new kind of small compound, prenylated resorcinol, isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens. Our previous studies showed that albaconol can inhibit tumor cell growth and dendritic cell maturation. However, the immunomodulatory roles and the underlying mechanisms of albaconol have not been fully understood. In this study we investigated the effects of albaconol on the proliferation and LPS-induced proinflammatory cytokine production of macrophages. Albaconol, when used at a dose higher than 1.0 mu g/ml, inhibited proliferation of RAW264.7 cells in a dose- and time-dependent manner, and could induce cellular apoptosis when used at high dosage (>= 7.5 mu g/ml). Furthermore, we found that albaconol used at a lower dosage without apoptosis induction could significantly inhibit LPS-induced TNF-alpha, IL-6, IL-1 beta and NO production in RAW264.7 cells. The inhibition of NF-kappa B activation and enhancement of SOCS1 expression in LPS-stimulated macrophages by albaconol may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Our results suggest that albaconol may be a potential immunosuppressive and anti-inflammatory drug.
关键词Immunosuppressant Macrophage Proinflammatory Cytokine Nf-kappa b Socs1
资助信息National Natural Science Foundation of China [30721091]; National Key Basic Research Program of China [2007CB512403]
学科领域Immunology
收录类别SCI
语种英语
WOS研究方向Immunology
WOS类目Immunology
WOS记录号WOS:000259166800004
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1709
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China
2.Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China
3.Zhejiang Univ, Inst Immunol, Hangzhou 310031, Zhejiang, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resourses W China, Kunming 650204, Peoples R China
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Liu, Qiuyan,Shu, Xiaoli,Wang, Li,et al. Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2008,5(4):271-278.
APA Liu, Qiuyan,Shu, Xiaoli,Wang, Li,Sun, Anna,Liu, Jikai,&Cao, Xuetao.(2008).Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression.CELLULAR & MOLECULAR IMMUNOLOGY,5(4),271-278.
MLA Liu, Qiuyan,et al."Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappa B activation and enhancing SOCS1 expression".CELLULAR & MOLECULAR IMMUNOLOGY 5.4(2008):271-278.
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