Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors
Zhang, Quan1,3; Jiang, Zhi-Yong1; Luo, Jie1; Cheng, Pi1,3; Ma, Yun-Bao1; Zhang, Xue-Mei1; Zhang, Feng-Xue2; Zhou, Jun1; Chen, Ji-Jun1
2008-08-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号18期号:16页码:4647-4650
摘要A series of alisol A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities and cytotoxicities in vitro. The preliminary investigation demonstrates that simple modifications of the parent structure of alisol A can produce a number of potentially important derivatives against HBV. The most active anti-HBV compound 6a showed high activities against the secretion of HBV surface antigen (IC(50) = 0.024 mM), HBV e antigen (IC(50) = 0.028 mM) and remarkable selective indices (SI(HBsAg) > 108, SI(HBeAg) > 93), which was selected for further evaluation as a novel HBV inhibitor. (C) 2008 Elsevier Ltd. All rights reserved.
关键词Anti-hbv Activity Alisol a Derivatives Synthesis
资助信息National Natural Science Foundation of China [30672522]; Xibu Zhiguang Joint-Scholarship ; Chinese Academy of Sciences [KSCX1-YW-R-24]
学科领域Chemistry ; Medicinal ; Chemistry ; Organic
DOI10.1016/j.bmcl.2008.07.012
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000258769200044
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1703
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Guangxi Univ Tradit Chinese Med, Inst Trop Med Sci, Guangzhou, Guangdong, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Zhang, Quan,Jiang, Zhi-Yong,Luo, Jie,et al. Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(16):4647-4650.
APA Zhang, Quan.,Jiang, Zhi-Yong.,Luo, Jie.,Cheng, Pi.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2008).Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(16),4647-4650.
MLA Zhang, Quan,et al."Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.16(2008):4647-4650.
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