| A small trypsin inhibitor from the frog of Odorrana grahami | |
| Li, Jianxu1,4; Wu, Jing1,4; Wang, Yipeng2,4; Xu, Xueqing2,4; Liu, Tongguang1; Lai, Ren1,2; Zhu, Huajie3 | |
| 2008-09-01 | |
| 发表期刊 | BIOCHIMIE
 |
| 卷号 | 90期号:9页码:1356-1361 |
| 摘要 | A novel peptide inhibitor (OGTI) of serine protease with a molecular weight of 1949.8, was purified from the skin secretion of the frog, Odorrana grahami. Of the tested serine proteases, OGTI only inhibited the hydrolysis activity of trypsin on synthetic chromogenic substrate. This precursor deduced from the cDNA sequence is composed of 70 amino acid residues. The mature OGTI contains 17 amino acid residues including a six-residue loop disulfided by two half-cysteines (AVNIPFKVHFRCKAAFC). In addition to its unique six-residue loop, the overall structure and precursor of OGTI are different from those of other serine protease inhibitors. It is also one of the smallest serine protease inhibitors ever found. (C) 2008 Elsevier Masson SAS. All rights reserved. |
| 关键词 | Serine Protease Inhibitor Amphibian Odorrana Grahami |
| DOI | 10.1016/j.biochi.2008.04.005 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259267700010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/1701 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Biotoxin Units, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 2.Nanjing Agr Univ, Key Lab Microbiol Engn Agricultural Environm, Minist Agr, Life Sci Coll, Nanjing 210095, Jiangsu, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650224, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jianxu,Wu, Jing,Wang, Yipeng,et al. A small trypsin inhibitor from the frog of Odorrana grahami[J]. BIOCHIMIE,2008,90(9):1356-1361. |
| APA | Li, Jianxu.,Wu, Jing.,Wang, Yipeng.,Xu, Xueqing.,Liu, Tongguang.,...&Zhu, Huajie.(2008).A small trypsin inhibitor from the frog of Odorrana grahami.BIOCHIMIE,90(9),1356-1361. |
| MLA | Li, Jianxu,et al."A small trypsin inhibitor from the frog of Odorrana grahami".BIOCHIMIE 90.9(2008):1356-1361. |
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