A small trypsin inhibitor from the frog of Odorrana grahami
Li, Jianxu1,4; Wu, Jing1,4; Wang, Yipeng2,4; Xu, Xueqing2,4; Liu, Tongguang1; Lai, Ren1,2; Zhu, Huajie3
2008-09-01
发表期刊BIOCHIMIE
卷号90期号:9页码:1356-1361
摘要A novel peptide inhibitor (OGTI) of serine protease with a molecular weight of 1949.8, was purified from the skin secretion of the frog, Odorrana grahami. Of the tested serine proteases, OGTI only inhibited the hydrolysis activity of trypsin on synthetic chromogenic substrate. This precursor deduced from the cDNA sequence is composed of 70 amino acid residues. The mature OGTI contains 17 amino acid residues including a six-residue loop disulfided by two half-cysteines (AVNIPFKVHFRCKAAFC). In addition to its unique six-residue loop, the overall structure and precursor of OGTI are different from those of other serine protease inhibitors. It is also one of the smallest serine protease inhibitors ever found. (C) 2008 Elsevier Masson SAS. All rights reserved.
关键词Serine Protease Inhibitor Amphibian Odorrana Grahami
DOI10.1016/j.biochi.2008.04.005
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology
WOS类目Biochemistry & Molecular Biology
WOS记录号WOS:000259267700010
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1701
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Biotoxin Units, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
2.Nanjing Agr Univ, Key Lab Microbiol Engn Agricultural Environm, Minist Agr, Life Sci Coll, Nanjing 210095, Jiangsu, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650224, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100009, Peoples R China
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Li, Jianxu,Wu, Jing,Wang, Yipeng,et al. A small trypsin inhibitor from the frog of Odorrana grahami[J]. BIOCHIMIE,2008,90(9):1356-1361.
APA Li, Jianxu.,Wu, Jing.,Wang, Yipeng.,Xu, Xueqing.,Liu, Tongguang.,...&Zhu, Huajie.(2008).A small trypsin inhibitor from the frog of Odorrana grahami.BIOCHIMIE,90(9),1356-1361.
MLA Li, Jianxu,et al."A small trypsin inhibitor from the frog of Odorrana grahami".BIOCHIMIE 90.9(2008):1356-1361.
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