Preparation and antitussive, expectorant, and antiasthmatic activities of verticinone's derivatives
Zhang, Yong-Hui1; Ruan, Han-Li1; Pi, Hui-Fang1; Wu, Ji-Zhou1; Sun, Han-Dong2; Fujita, Tetsuro3
2008
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷号10期号:7页码:627-633
摘要To prepare verticinone derivatives with significant antitussive, expectorant, and antiasthmatic activities, the compounds 3 beta-acetylverticinone (1), 3-ketoverticinone (2), 3b-benzoylverticinone (3), 3 beta-propionylverticinone (4), 3 beta-butyrylverticinone (5), and 3 beta-butoxycarbonylverticinone (6) have been prepared. All of these are new compounds. Among them, 1-6 exhibited potent antitussive and expectorant activities; 1 and 3-6 displayed various antiasthmatic activities. The antitussive activity of 1-6, the expectorant activity of 1-2 and 4-6, and the antiasthmatic activity of 1 are higher than those of verticinone. The results demonstrated that 1 had dominant biological activities, suggesting that it would be a potential antitussive, expectorant, and antiasthmatic agent.
关键词Verticinone 3 Beta-acetylverticinone Derivative Antitussive Expectorant Antiasthmatic
DOI10.1080/10286020802133480
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000259658800007
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1697
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Fac Pharmaceut Sci, Wuhan 430074, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
3.Kyoto Univ, Fac Pharmaceut Sci, Kyoto 606, Japan
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GB/T 7714
Zhang, Yong-Hui,Ruan, Han-Li,Pi, Hui-Fang,et al. Preparation and antitussive, expectorant, and antiasthmatic activities of verticinone's derivatives[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2008,10(7):627-633.
APA Zhang, Yong-Hui,Ruan, Han-Li,Pi, Hui-Fang,Wu, Ji-Zhou,Sun, Han-Dong,&Fujita, Tetsuro.(2008).Preparation and antitussive, expectorant, and antiasthmatic activities of verticinone's derivatives.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,10(7),627-633.
MLA Zhang, Yong-Hui,et al."Preparation and antitussive, expectorant, and antiasthmatic activities of verticinone's derivatives".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 10.7(2008):627-633.
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