Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells

doi:10.1186/1860-5397-3-3

	Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells
	Sun, Li-Rong ; Qing, Chen ; Zhang, Yan-Li ; Jia, Shu-Yu ; Li, Zhong-Rong ; Pei, Shen-Ji ; Qiu, Ming-Hua; Gross, Michael L.; Qiu, Samuel X.
	2007-01-31
发表期刊	BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷号	3 页码:3
摘要	Two new cycloartane-type triterpene glycosides, namely cimicifoetisides A ( 1) and B ( 2), along with seven known compounds cimigenol, 25-O-acetylcimigenol, cimigenol 3-O-beta-D-xylopyranoside, 12 beta-hydroxycimigenol 3-O-beta-D-xylopyranoside, cimigenol 3-O-alpha-L-arabinopyranoside, 25-deoxyshengmanol 3-O-beta-D-xylopyranoside and cimilactone A, were isolated from the rhizomes of Cimicifuga foetida. Their structures were elucidated as cimigenol 3-O-( 2'-O-acetyl)-alpha-L-arabinopyranoside ( 1) and 25-O-acetylcimigenol 3-O-( 2'-O-acetyl)-alpha-L-arabinopyranoside ( 2). Both compounds 1 and 2 exhibited potent cytotoxicity against rat EAC ( Ehrlich ascites carcinoma) and MDA-MB-A231 ( human breast cancer) cells with IC50 values of 0.52 and 6.74 mu M for 1, and 0.19 and 10.21 mu M for 2, suggesting their potential for further investigation as anti-cancer agents.
学科领域	Chemistry, Organic
DOI	10.1186/1860-5397-3-3
收录类别	SCI
语种	英语
WOS记录号	WOS:000244418500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1679
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China 2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China 3.Washington Univ, Dept Chem, St Louis, MO 63130 USA 4.Herbstandard Inc, Nat Prod Drug Discovery, Argonne, IL 60439 USA
推荐引用方式 GB/T 7714	Sun, Li-Rong,Qing, Chen,Zhang, Yan-Li,et al. Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2007,3:3.
APA	Sun, Li-Rong.,Qing, Chen.,Zhang, Yan-Li.,Jia, Shu-Yu.,Li, Zhong-Rong.,...&Qiu, Samuel X..(2007).Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,3,3.
MLA	Sun, Li-Rong,et al."Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 3(2007):3.

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