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题名: Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells
作者: Sun, Li-Rong; Qing, Chen; Zhang, Yan-Li; Jia, Shu-Yu; Li, Zhong-Rong; Pei, Shen-Ji; null(邱明华); Gross, Michael L.; Qiu, Samuel X.
刊名: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
英文摘要: Two new cycloartane-type triterpene glycosides, namely cimicifoetisides A ( 1) and B ( 2), along with seven known compounds cimigenol, 25-O-acetylcimigenol, cimigenol 3-O-beta-D-xylopyranoside, 12 beta-hydroxycimigenol 3-O-beta-D-xylopyranoside, cimigenol 3-O-alpha-L-arabinopyranoside, 25-deoxyshengmanol 3-O-beta-D-xylopyranoside and cimilactone A, were isolated from the rhizomes of Cimicifuga foetida. Their structures were elucidated as cimigenol 3-O-( 2'-O-acetyl)-alpha-L-arabinopyranoside ( 1) and 25-O-acetylcimigenol 3-O-( 2'-O-acetyl)-alpha-L-arabinopyranoside ( 2). Both compounds 1 and 2 exhibited potent cytotoxicity against rat EAC ( Ehrlich ascites carcinoma) and MDA-MB-A231 ( human breast cancer) cells with IC50 values of 0.52 and 6.74 mu M for 1, and 0.19 and 10.21 mu M for 2, suggesting their potential for further investigation as anti-cancer agents.
出版日期: 2007-01-31
卷号: 3, 页码:3
DOI标识: 10.1186/1860-5397-3-3
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1679
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
3.Washington Univ, Dept Chem, St Louis, MO 63130 USA
4.Herbstandard Inc, Nat Prod Drug Discovery, Argonne, IL 60439 USA

Recommended Citation:
Sun LR; Qing C; Zhang YL; Jia SY; Li ZR ; Pei SJ;Qiu MH; Gross ML; Qiu SX.Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells,BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2007,3():3
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