Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells
Sun, Li-Rong; Qing, Chen; Zhang, Yan-Li; Jia, Shu-Yu; Li, Zhong-Rong; Pei, Shen-Ji; Qiu, Ming-Hua; Gross, Michael L.; Qiu, Samuel X.
2007-01-31
发表期刊BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷号3页码:3
摘要Two new cycloartane-type triterpene glycosides, namely cimicifoetisides A ( 1) and B ( 2), along with seven known compounds cimigenol, 25-O-acetylcimigenol, cimigenol 3-O-beta-D-xylopyranoside, 12 beta-hydroxycimigenol 3-O-beta-D-xylopyranoside, cimigenol 3-O-alpha-L-arabinopyranoside, 25-deoxyshengmanol 3-O-beta-D-xylopyranoside and cimilactone A, were isolated from the rhizomes of Cimicifuga foetida. Their structures were elucidated as cimigenol 3-O-( 2'-O-acetyl)-alpha-L-arabinopyranoside ( 1) and 25-O-acetylcimigenol 3-O-( 2'-O-acetyl)-alpha-L-arabinopyranoside ( 2). Both compounds 1 and 2 exhibited potent cytotoxicity against rat EAC ( Ehrlich ascites carcinoma) and MDA-MB-A231 ( human breast cancer) cells with IC50 values of 0.52 and 6.74 mu M for 1, and 0.19 and 10.21 mu M for 2, suggesting their potential for further investigation as anti-cancer agents.
学科领域Chemistry, Organic
DOI10.1186/1860-5397-3-3
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000244418500001
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1679
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
2.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
3.Washington Univ, Dept Chem, St Louis, MO 63130 USA
4.Herbstandard Inc, Nat Prod Drug Discovery, Argonne, IL 60439 USA
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Sun, Li-Rong,Qing, Chen,Zhang, Yan-Li,et al. Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2007,3:3.
APA Sun, Li-Rong.,Qing, Chen.,Zhang, Yan-Li.,Jia, Shu-Yu.,Li, Zhong-Rong.,...&Qiu, Samuel X..(2007).Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,3,3.
MLA Sun, Li-Rong,et al."Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 3(2007):3.
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