| Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities | |
Wang, Wei-Guang1; Wu, Zhao-Yuan1; Chen, Rui2; Li, Hai-Zhou1; Li, Hong-Mei1; Li, Yuan-Dan1; Li, Rong-Tao1; Luo, Huai-Rong2
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| 通讯作者 | Li, RT (reprint author), Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Peoples R China. ; rongtaolikm@gmail.com ; luohuairong@mail.kib.ac.cn |
| 2013-06-01 | |
| 发表期刊 | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| 卷号 | 10期号:6页码:1061-1071 |
| 摘要 | Four highly acylated diterpenoids, designated as pierisformotoxins A-D (1-4, resp.), along with 26 known compounds, were isolated from the flowers of Pieris formosa. Among them, pierisformotoxins A and B (1 and 2, resp.) were new highly acylated grayanane diterpenoids, of which the five-membered ring A has undergone an oxidative cleavage between C(3) and C(4), followed by lactonization, to give rise to a five-membered lactone ring between C(3) and C(5), differing from the previously reported grayanane diterpenoids with a 5/7/6/5 ring system. Results of the cAMP-regulation-activity assay showed that pierisformotoxin C (3) at 10M (inhibitory ratio (IR): 10.1%) or 2M (9.8%), and pierisformotoxin B (2) at 50M (13.9%) significantly decreased the cAMP level in N1E-115 neuroblastoma cells (p<0.05). |
| 关键词 | Pieris Formosa Grayanane Diterpenoids Pierisformotoxins A-d Cyclic Adenosine Monophosphate (Camp) Regulation Activity |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320543600007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16781 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wei-Guang,Wu, Zhao-Yuan,Chen, Rui,et al. Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities[J]. CHEMISTRY & BIODIVERSITY,2013,10(6):1061-1071. |
| APA | Wang, Wei-Guang.,Wu, Zhao-Yuan.,Chen, Rui.,Li, Hai-Zhou.,Li, Hong-Mei.,...&Luo, Huai-Rong.(2013).Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities.CHEMISTRY & BIODIVERSITY,10(6),1061-1071. |
| MLA | Wang, Wei-Guang,et al."Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities".CHEMISTRY & BIODIVERSITY 10.6(2013):1061-1071. |
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