Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities
Wang, Wei-Guang1; Wu, Zhao-Yuan1; Chen, Rui2; Li, Hai-Zhou1; Li, Hong-Mei1; Li, Yuan-Dan1; Li, Rong-Tao1; Luo, Huai-Rong2
2013-06-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号10期号:6页码:1061-1071
摘要Four highly acylated diterpenoids, designated as pierisformotoxins A-D (1-4, resp.), along with 26 known compounds, were isolated from the flowers of Pieris formosa. Among them, pierisformotoxins A and B (1 and 2, resp.) were new highly acylated grayanane diterpenoids, of which the five-membered ring A has undergone an oxidative cleavage between C(3) and C(4), followed by lactonization, to give rise to a five-membered lactone ring between C(3) and C(5), differing from the previously reported grayanane diterpenoids with a 5/7/6/5 ring system. Results of the cAMP-regulation-activity assay showed that pierisformotoxin C (3) at 10M (inhibitory ratio (IR): 10.1%) or 2M (9.8%), and pierisformotoxin B (2) at 50M (13.9%) significantly decreased the cAMP level in N1E-115 neuroblastoma cells (p<0.05).
关键词Pieris Formosa Grayanane Diterpenoids Pierisformotoxins A-d Cyclic Adenosine Monophosphate (Camp) Regulation Activity
资助信息National Natural Science Foundation of China [20862011]; Fok Ying-Tong Education Foundation [111040]; Department of Science and Technology in Yunnan Province [20080A007]; Specialized Research Fund for the Doctoral Program of Higher Education [20095314110001]; Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2009-KF05]
学科领域Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000320543600007
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16781
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Wang, Wei-Guang,Wu, Zhao-Yuan,Chen, Rui,et al. Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities[J]. CHEMISTRY & BIODIVERSITY,2013,10(6):1061-1071.
APA Wang, Wei-Guang.,Wu, Zhao-Yuan.,Chen, Rui.,Li, Hai-Zhou.,Li, Hong-Mei.,...&Luo, Huai-Rong.(2013).Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities.CHEMISTRY & BIODIVERSITY,10(6),1061-1071.
MLA Wang, Wei-Guang,et al."Pierisformotoxins A-D, Polyesterified Grayanane Diterpenoids from Pieris formosa and Their cAMP-Decreasing Activities".CHEMISTRY & BIODIVERSITY 10.6(2013):1061-1071.
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