Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization

	Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization
	Huang, Jiu-Zhong 1,2; Jie, Xiao-Ke 1,3; Wei, Kun 1; Zhang, Hongbin 2; Wang, Min-Cai 3; Yang, Yu-Rong1
	2013-06-01
发表期刊	SYNLETT
ISSN	0936-5214
卷号	24 期号:10 页码:1303-1306
摘要	A formal synthesis of aspidospermidine is reported through a novel preparation of Stork's penultimate tricyclic ketone intermediate. The key steps of the synthesis consist of an intramolecular cascade transannular cyclization, triggered by the removal of Boc group, which simultaneously forms the C, D, and E rings of aspidospermidine and conveniently setting up the quaternary stereo-center via decarboxylative alkylation reaction of the beta-keto ester.
关键词	Alkaloid Total Synthesis Palladium Cross-coupling Cyclization
资助信息	National Natural Science of China [81102348, 21072200]; Chinese Academy of Sciences
学科领域	Chemistry, Organic
收录类别	SCI ; IC ; CCR
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000320576300028
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16779
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Yunnan Univ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 3.Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China
推荐引用方式 GB/T 7714	Huang, Jiu-Zhong,Jie, Xiao-Ke,Wei, Kun,et al. Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization[J]. SYNLETT,2013,24(10):1303-1306.
APA	Huang, Jiu-Zhong,Jie, Xiao-Ke,Wei, Kun,Zhang, Hongbin,Wang, Min-Cai,&Yang, Yu-Rong.(2013).Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization.SYNLETT,24(10),1303-1306.
MLA	Huang, Jiu-Zhong,et al."Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization".SYNLETT 24.10(2013):1303-1306.

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