Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162
He, Fei1; Bao, Jie1; Zhang, Xiao-Yong1; Tu, Zheng-Chao2; Shi, Yi-Ming3; Qi, Shu-Hua1
通讯作者Qi, SH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, 164 West Xingang, Guangzhou 510301, Guangdong, Peoples R China. ; shuhuaqi@scsio.ac.cn
2013-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:6页码:1182-1186
摘要A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A(1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (A), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162:. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique, and analysis of the acid hydrolysates using a chiral, phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.
关键词Cyanobacterium Lyngbya-majuscula Metabolites Biosynthesis Derivatives Agents
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
收录类别SCI ; IC
语种英语
WOS记录号WOS:000321320600026
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16777
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650204, Peoples R China
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GB/T 7714
He, Fei,Bao, Jie,Zhang, Xiao-Yong,et al. Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(6):1182-1186.
APA He, Fei,Bao, Jie,Zhang, Xiao-Yong,Tu, Zheng-Chao,Shi, Yi-Ming,&Qi, Shu-Hua.(2013).Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162.JOURNAL OF NATURAL PRODUCTS,76(6),1182-1186.
MLA He, Fei,et al."Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162".JOURNAL OF NATURAL PRODUCTS 76.6(2013):1182-1186.
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