Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162
He, Fei1; Bao, Jie1; Zhang, Xiao-Yong1; Tu, Zheng-Chao2; Shi, Yi-Ming3; Qi, Shu-Hua1
2013-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:6页码:1182-1186
摘要A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A(1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (A), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162:. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique, and analysis of the acid hydrolysates using a chiral, phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.
关键词Cyanobacterium Lyngbya-majuscula Metabolites Biosynthesis Derivatives Agents
资助信息National Basic Research Program of China (973 Program) [2010CB833803]; National Natural Science Foundation of China [41206130]; National High Technology Research and Development Program of China (863 Program) [2012AA092104]; National Marine Public Welfare Research Project of China [201305017]; Chinese Academy of Sciences [5060267]
收录类别SCI ; IC
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16777
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650204, Peoples R China
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He, Fei,Bao, Jie,Zhang, Xiao-Yong,et al. Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(6):1182-1186.
APA He, Fei,Bao, Jie,Zhang, Xiao-Yong,Tu, Zheng-Chao,Shi, Yi-Ming,&Qi, Shu-Hua.(2013).Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162.JOURNAL OF NATURAL PRODUCTS,76(6),1182-1186.
MLA He, Fei,et al."Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162".JOURNAL OF NATURAL PRODUCTS 76.6(2013):1182-1186.
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