Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy
Yang, Yang1,3; Yan, Yong-Ming1; Wei, Wei4; Luo, Jie1; Zhang, Lan-Sheng1; Zhou, Xiao-Jiang4; Wang, Peng-Cheng1; Yang, Yong-Xun2; Cheng, Yong-Xian1
2013-07-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号23期号:13页码:3905-3909
摘要Two new oxanthrone C-glycosides, patientosides A (14) and B (15), together with three known ones (11-13), were isolated from Rumex patientia. Their structures were identified on the basis of spectroscopic methods. The absolute configuration for 14 and 15 were deduced by analysis of their CD spectra and comparison with those of known similar compounds. Compounds 11-15, and 14 known anthraquinones (1-4, 6-10, 16-20) previously isolated from Rumex nepalensis, Rumex hastatus, and endophytic Aspergillus fumigatus, respectively, as well as a commercially available compound rhein (5) were evaluated for their inhibitory effects on IL-6 and extracellular matrix production in mesangial cells. (c) 2013 Elsevier Ltd. All rights reserved.
关键词Anthraquinone Oxanthrone C-glycoside Diabetic Nephropathy Rumex Endophytic Aspergillus Fumigatus
资助信息National Natural Science Foundation of China [20972165]; Key Project for Drug Innovation from the Ministry of Science and Technology of China [2012ZX09103-201-052]; Open Research Fund of State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004]; Project of Natural Compound Library Construction from Chinese Academy of Sciences [KSCX2-EW-R-15]
学科领域Chemistry, Medicinal ; Chemistry, Organic
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000320702900045
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16757
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
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Yang, Yang,Yan, Yong-Ming,Wei, Wei,et al. Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(13):3905-3909.
APA Yang, Yang.,Yan, Yong-Ming.,Wei, Wei.,Luo, Jie.,Zhang, Lan-Sheng.,...&Cheng, Yong-Xian.(2013).Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(13),3905-3909.
MLA Yang, Yang,et al."Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.13(2013):3905-3909.
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