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题名: A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata
作者: Huang Sheng-Dian1, 2; Zhang Yu1; He Hong-Ping1; Li Shi-Fei1, 2; Tang Gui-Hua1, 2; Chen Duo-Zhi1, 2; Cao Ming-Ming1, 2; Di Ying-Tong1; Hao Xiao-Jiang1
刊名: CHINESE JOURNAL OF NATURAL MEDICINES
关键词: Lycoris radiata ; Amaryllidaceae alkaloids ; Homolycorine-type ; 2 alpha-Methoxy-6-O-methyloduline ; 2 alpha-Methoxy-6-beta-ethyloduline
英文摘要: AIM: To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata. METHODS: The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A. RESULTS: One new homolycorine-type alkaloid 2 alpha-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2 alpha-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6 alpha-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained. CONCLUSION: Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 mu g.mL(-1) and CC50 values of 14.37, 4.79, and 80.12 mu g.ml(-1), respectively.
出版日期: 2013-07-01
卷号: 11, 期号:4, 页码:406-410
语种: 英语
收录类别: SCI
学科分类: Integrative & Complementary Medicine; Pharmacology & Pharmacy
ISSN号: 1672-3651
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16753
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Huang Sheng-Dian; Zhang Yu; He Hong-Ping; Li Shi-Fei; Tang Gui-Hua; Chen Duo-Zhi; Cao Ming-Ming; Di Ying-Tong; Hao Xiao-Jiang.A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata,CHINESE JOURNAL OF NATURAL MEDICINES,2013,11(4):406-410
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