A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata
Huang Sheng-Dian1,2; Zhang Yu1; He Hong-Ping1; Li Shi-Fei1,2; Tang Gui-Hua1,2; Chen Duo-Zhi1,2; Cao Ming-Ming1,2; Di Ying-Tong1; Hao Xiao-Jiang1
2013-07-01
发表期刊CHINESE JOURNAL OF NATURAL MEDICINES
ISSN1672-3651
卷号11期号:4页码:406-410
摘要AIM: To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata. METHODS: The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A. RESULTS: One new homolycorine-type alkaloid 2 alpha-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2 alpha-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6 alpha-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained. CONCLUSION: Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 mu g.mL(-1) and CC50 values of 14.37, 4.79, and 80.12 mu g.ml(-1), respectively.
关键词Lycoris Radiata Amaryllidaceae Alkaloids Homolycorine-type 2 Alpha-methoxy-6-o-methyloduline 2 Alpha-methoxy-6-beta-ethyloduline
资助信息National Natural Science Foundation of China [30830114]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2009CI072]; National Natural Science Foundation of China(30830114); Young Academic and Technical Leader Raising Foundation of Yunnan Province(2009CI072)
学科领域Integrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI10.3724/SP.J.1009.2013.00406
收录类别SCI
语种英语
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS类目Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号WOS:000322299000012
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16753
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Huang Sheng-Dian,Zhang Yu,He Hong-Ping,et al. A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2013,11(4):406-410.
APA Huang Sheng-Dian.,Zhang Yu.,He Hong-Ping.,Li Shi-Fei.,Tang Gui-Hua.,...&Hao Xiao-Jiang.(2013).A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata.CHINESE JOURNAL OF NATURAL MEDICINES,11(4),406-410.
MLA Huang Sheng-Dian,et al."A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata".CHINESE JOURNAL OF NATURAL MEDICINES 11.4(2013):406-410.
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