A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata
Huang Sheng-Dian1,2; Zhang Yu1; He Hong-Ping1; Li Shi-Fei1,2; Tang Gui-Hua1,2; Chen Duo-Zhi1,2; Cao Ming-Ming1,2; Di Ying-Tong1; Hao Xiao-Jiang1
Corresponding AuthorHao, XJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; diyt@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
2013-07-01
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
ISSN1672-3651
Volume11Issue:4Pages:406-410
AbstractAIM: To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata. METHODS: The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A. RESULTS: One new homolycorine-type alkaloid 2 alpha-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2 alpha-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6 alpha-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained. CONCLUSION: Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 mu g.mL(-1) and CC50 values of 14.37, 4.79, and 80.12 mu g.ml(-1), respectively.
KeywordLycoris Radiata Amaryllidaceae Alkaloids Homolycorine-type 2 Alpha-methoxy-6-o-methyloduline 2 Alpha-methoxy-6-beta-ethyloduline
Subject AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI10.3724/SP.J.1009.2013.00406
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000322299000012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16753
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Huang Sheng-Dian,Zhang Yu,He Hong-Ping,et al. A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2013,11(4):406-410.
APA Huang Sheng-Dian.,Zhang Yu.,He Hong-Ping.,Li Shi-Fei.,Tang Gui-Hua.,...&Hao Xiao-Jiang.(2013).A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata.CHINESE JOURNAL OF NATURAL MEDICINES,11(4),406-410.
MLA Huang Sheng-Dian,et al."A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata".CHINESE JOURNAL OF NATURAL MEDICINES 11.4(2013):406-410.
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